Bousfield, R;
Thyl, M;
Samol, O;
Rithea, L;
Sona, S;
Chhat, HP;
Poda, S;
Moore, CE;
Chheng, K;
Kumar, V;
et al.
Bousfield, R; Thyl, M; Samol, O; Rithea, L; Sona, S; Chhat, HP; Poda, S; Moore, CE; Chheng, K; Kumar, V; Day, NPJ; Parry, CM
(2016)
A retrospective study of factors which determine a negative blood culture in Cambodian children diagnosed with enteric fever.
Paediatr Int Child Health, 36 (2).
pp. 118-121.
ISSN 2046-9055
https://doi.org/10.1179/2046905515Y.0000000009
SGUL Authors: Moore, Catrin Elisabeth
Abstract
BACKGROUND: Blood cultures are used to confirm a diagnosis of enteric fever but reported sensitivities can be as low as 40%. AIMS: To determine the factors associated with a negative blood culture in Cambodian children with suspected enteric fever. METHODS: In a retrospective study of hospitalised Cambodian children given a discharge diagnosis of enteric fever, the following factors associated with a negative blood culture were analysed: age, blood culture volume, prior antibiotic therapy, duration of illness and disease severity. RESULTS: In 227 hospitalised Cambodian children with a discharge diagnosis of enteric fever, it was confirmed in 70% by a positive blood culture. There was no association between a negative blood culture and younger age, lower blood volumes for culture, prior antibiotic therapy, a late presentation or milder disease. CONCLUSIONS: Although blood culture sensitivity was higher than expected, alternative simple, rapid and sensitive tests are needed for diagnosing enteric fever.
Item Type: |
Article
|
Additional Information: |
© 2016 The Authors. Published by Informa UK Limited, trading as Taylor & Francis Group
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
Keywords: |
Angkor Hospital for Children, Blood culture, Cambodia, Children, Enteric fever, Paediatric, Salmonella, Typhoid, Bacteriological Techniques, Blood Culture, Cambodia, Child, Child, Preschool, Female, Humans, Male, Retrospective Studies, Salmonella typhi, Sensitivity and Specificity, Typhoid Fever, Humans, Salmonella typhi, Typhoid Fever, Bacteriological Techniques, Sensitivity and Specificity, Retrospective Studies, Child, Child, Preschool, Cambodia, Female, Male, Blood Culture, Enteric fever, Typhoid, Cambodia, Children, Blood culture, Salmonella, Paediatric, Angkor Hospital for Children |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Paediatr Int Child Health |
ISSN: |
2046-9055 |
Language: |
eng |
Dates: |
Date | Event |
---|
May 2016 | Published | 27 April 2016 | Published Online |
|
Publisher License: |
Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 |
Projects: |
Project ID | Funder | Funder ID |
---|
UNSPECIFIED | Mahidol-Oxford Tropical Medicine Research Unit | UNSPECIFIED |
|
PubMed ID: |
25845519 |
Web of Science ID: |
WOS:000375150800007 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/114485 |
Publisher's version: |
https://doi.org/10.1179/2046905515Y.0000000009 |
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