Howarth, CN; Leung, TS; Banerjee, J; Eaton, S; Morris, JK; Aladangady, N
(2022)
Regional cerebral and splanchnic tissue oxygen saturation in preterm infants - Longitudinal normative measurements.
Early Hum Dev, 165.
p. 105540.
ISSN 1872-6232
https://doi.org/10.1016/j.earlhumdev.2022.105540
SGUL Authors: Morris, Joan Katherine
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Abstract
BACKGROUND: To investigate regional splanchnic and cerebral tissue oxygen saturation in preterm infants <30 weeks gestation. METHODS: Cerebral (cTOI) and splanchnic (sTOI) Tissue Oxygenation Index were measured weekly in 5 min epochs for a total period of 60 min using NIRS (NIRO-300) for the first 8 weeks of life, in 48 appropriately grown preterm infants born at <30 weeks gestation. Infants who developed HPI and/or NEC (n = 12) and those that died (n = 1) were excluded from our main outcome measure of regional gut and cerebral tissue oxygenation in healthy preterm infants <30 weeks gestation. RESULTS: Median birthweight 789 g (460-1486), gestational age 25+6 weeks (23+0-29+1) and 51.4% female. 217 NIRS measurements were completed across the first 8 weeks of life. Mean weekly cTOI ranged from 56.8-65.4% and sTOI ranged from 36.7-46.0%. Mean cTOI was significantly higher than mean sTOI (p < 0.001) throughout the first 8 weeks of life. Mean cTOI decreased significantly with increasing postnatal age [-0.59% each week (-1.26% to -0.07%) p = 0.04]. None of the examined confounding factors had a significant effect. CONCLUSIONS: This is the first report of regional cerebral and splanchnic tissue oxygen saturation ranges during the first 8 weeks of life for preterm infants born at <30 weeks gestation.
Item Type: | Article | ||||||
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Additional Information: | © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | ||||||
Keywords: | NEC, NIRS, Preterm infants, Regional oxygen saturation, Pediatrics, 1103 Clinical Sciences, 1702 Cognitive Sciences | ||||||
SGUL Research Institute / Research Centre: | Academic Structure > Population Health Research Institute (INPH) | ||||||
Journal or Publication Title: | Early Hum Dev | ||||||
ISSN: | 1872-6232 | ||||||
Language: | eng | ||||||
Publisher License: | Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 | ||||||
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PubMed ID: | 35065416 | ||||||
Go to PubMed abstract | |||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/114173 | ||||||
Publisher's version: | https://doi.org/10.1016/j.earlhumdev.2022.105540 |
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