Hart, MG; Romero-Garcia, R; Price, SJ; Suckling, J
(2019)
Global Effects of Focal Brain Tumors on Functional Complexity and Network Robustness: A Prospective Cohort Study.
Neurosurgery, 84 (6).
pp. 1201-1213.
ISSN 1524-4040
https://doi.org/10.1093/neuros/nyy378
SGUL Authors: Hart, Michael Gavin
Abstract
BACKGROUND: Neurosurgical management of brain tumors has entered a paradigm of supramarginal resections that demands thorough understanding of peritumoral functional effects. Historically, the effects of tumors have been believed to be local, and long-range effects have not been considered. OBJECTIVE: To test the hypothesis that tumors affect the brain globally, producing long-range gradients in cortical function. METHODS: Resting-state functional magnetic resonance imaging (fMRI) data were acquired from 11 participants with glioblastoma and split into discovery and validation datasets in a single-center prospective cohort study. Fractal complexity was computed with a wavelet-based estimator of the Hurst exponent. Distance-related effects of the tumors were tested with a tumor mask-dilation technique and parcellation of the underlying Hurst maps. RESULTS: Fractal complexity demonstrates a penumbra of suppression in the peritumoral region. At a global level, as distance from the tumor increases, this initial suppression is balanced by a subsequent overactivity before finally normalizing. These effects were best fit by a quadratic model and were consistent across different network construction pipelines. The Hurst exponent was correlated with graph theory measures of centrality including network robustness, but graph theory measures did not demonstrate distance-dependent effects. CONCLUSION: This work provides evidence supporting the theory that focal brain tumors produce long-range gradients in function. Consequently, the effects of focal lesions need to be interpreted in terms of the global changes on functional complexity and network architecture rather than purely in terms of functional localization. Determining whether peritumoral changes represent potential plasticity may facilitate extended resection of tumors without functional cost.
Item Type: |
Article
|
Additional Information: |
© Congress of Neurological Surgeons 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: |
Connectome, Fractal, Functional MRI, Glioblastoma, Neurooncology, Adult, Aged, Brain, Brain Mapping, Brain Neoplasms, Connectome, Female, Fractals, Glioblastoma, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Prospective Studies, Brain, Nerve Net, Humans, Glioblastoma, Brain Neoplasms, Magnetic Resonance Imaging, Brain Mapping, Prospective Studies, Fractals, Adult, Aged, Middle Aged, Female, Male, Connectome, 1103 Clinical Sciences, 1109 Neurosciences, Neurology & Neurosurgery |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: |
Neurosurgery |
ISSN: |
1524-4040 |
Language: |
eng |
Dates: |
Date | Event |
---|
1 June 2019 | Published | 22 August 2018 | Published Online | 19 July 2018 | Accepted |
|
Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
|
PubMed ID: |
30137556 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/113746 |
Publisher's version: |
https://doi.org/10.1093/neuros/nyy378 |
Statistics
Item downloaded times since 11 Oct 2021.
Actions (login required)
![Edit Item](/style/images/action_view.png) |
Edit Item |