Marlow, N;
Ni, Y;
Lancaster, R;
Suonpera, E;
Bernardi, M;
Fahy, A;
Larsen, J;
Trickett, J;
Hurst, JR;
Morris, J;
et al.
Marlow, N; Ni, Y; Lancaster, R; Suonpera, E; Bernardi, M; Fahy, A; Larsen, J; Trickett, J; Hurst, JR; Morris, J; Wolke, D; Johnson, S
(2021)
No change in neurodevelopment at 11 years after extremely preterm birth.
Arch Dis Child Fetal Neonatal Ed, 106 (4).
pp. 418-424.
ISSN 1468-2052
https://doi.org/10.1136/archdischild-2020-320650
SGUL Authors: Morris, Joan Katherine
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Abstract
OBJECTIVE: To determine whether improvements in school age outcomes had occurred between two cohorts of births at 22-25 weeks of gestation to women residents in England in 1995 and 2006. DESIGN: Longitudinal national cohort studies. SETTING: School-based or home-based assessments at 11 years of age. PARTICIPANTS: EPICure2 cohort of births at 22-26 weeks of gestation in England during 2006: a sample of 200 of 1031 survivors were evaluated; outcomes for 112 children born at 22-25 weeks of gestation were compared with those of 176 born in England during 1995 from the EPICure cohort. Classroom controls for each group acted as a reference population. MAIN OUTCOME MEASURES: Standardised measures of cognition and academic attainment were combined with parent report of other impairments to estimate overall neurodevelopmental status. RESULTS: At 11 years in EPICure2, 18% had severe and 20% moderate impairments. Comparing births at 22-25 weeks in EPICure2 (n=112), 26% had severe and 21% moderate impairment compared with 18% and 32%, respectively, in EPICure. After adjustment, the OR of moderate or severe neurodevelopmental impairment in 2006 compared with 1995 was 0.76 (95% CI 0.45 to 1.31, p=0.32). IQ scores were similar in 1995 (mean 82.7, SD 18.4) and 2006 (81.4, SD 19.2), adjusted difference in mean z-scores 0.2 SD (95% CI -0.2 to 0.6), as were attainment test scores. The use of multiple imputation did not alter these findings. CONCLUSION: Improvements in care and survival between 1995 and 2006 are not paralleled by improved cognitive or educational outcomes or a reduced rate of neurodevelopmental impairment.
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