Kakhi, S; Phanish, MK; Anderson, L
(2020)
Dilated Cardiomyopathy in an Adult Renal Transplant Recipient: Recovery Upon Tacrolimus to Sirolimus Switch: A Case Report.
Transplant Proc, 52 (9).
pp. 2758-2761.
ISSN 1873-2623
https://doi.org/10.1016/j.transproceed.2020.06.011
SGUL Authors: Anderson, Lisa
Abstract
The objective of immunosuppressive drugs used in solid organ transplantation is to achieve acceptable rejection rates, minimize infections, and prolong graft and patient survival. Cardiovascular disease is a major cause of death in kidney transplant recipients. The drugs commonly used to prevent rejection (calcineurin inhibitors [CNIs] and steroids) contribute to cardiac disease seen in transplant patients by increasing the risk of hypertension and diabetes. Direct cardiac toxicity of chemotherapeutic drugs such as doxorubicin is well-known but potential direct effect of CNIs on myocardium is less explored and understood. Cardiac toxicity a rare but serious adverse effect of tacrolimus, has been observed in patients receiving solid organ transplants such as liver, bowel and kidney. In this report, we describe a case of new onset severe dilated cardiomyopathy after kidney transplantation. Reversal of heart failure occurred after tacrolimus discontinuation and the switch to a mammalian target of rapamycin (mTOR) inhibitor: sirolimus.
Item Type: |
Article
|
Additional Information: |
© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Keywords: |
Cardiomyopathy, Dilated, Female, Graft Rejection, Humans, Immunosuppressive Agents, Kidney Transplantation, Middle Aged, Sirolimus, Tacrolimus, Humans, Cardiomyopathy, Dilated, Sirolimus, Tacrolimus, Immunosuppressive Agents, Kidney Transplantation, Graft Rejection, Middle Aged, Female, 11 Medical and Health Sciences |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: |
Transplant Proc |
ISSN: |
1873-2623 |
Language: |
eng |
Dates: |
Date | Event |
---|
November 2020 | Published | 20 July 2020 | Published Online | 4 June 2020 | Accepted |
|
Publisher License: |
Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 |
PubMed ID: |
32703671 |
Web of Science ID: |
WOS:000585100600037 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/113686 |
Publisher's version: |
https://doi.org/10.1016/j.transproceed.2020.06.011 |
Statistics
Item downloaded times since 27 Sep 2021.
Actions (login required)
![Edit Item](/style/images/action_view.png) |
Edit Item |