So, R;
Chen, J;
Mehta, AJ;
Liu, S;
Strak, M;
Wolf, K;
Hvidtfeldt, UA;
Rodopoulou, S;
Stafoggia, M;
Klompmaker, JO;
et al.
So, R; Chen, J; Mehta, AJ; Liu, S; Strak, M; Wolf, K; Hvidtfeldt, UA; Rodopoulou, S; Stafoggia, M; Klompmaker, JO; Samoli, E; Raaschou-Nielsen, O; Atkinson, R; Bauwelinck, M; Bellander, T; Boutron-Ruault, M-C; Brandt, J; Brunekreef, B; Cesaroni, G; Concin, H; Forastiere, F; van Gils, CH; Gulliver, J; Hertel, O; Hoffmann, B; de Hoogh, K; Janssen, N; Lim, Y-H; Westendorp, R; Jørgensen, JT; Katsouyanni, K; Ketzel, M; Lager, A; Lang, A; Ljungman, PL; Magnusson, PKE; Nagel, G; Simonsen, MK; Pershagen, G; Peter, RS; Peters, A; Renzi, M; Rizzuto, D; Sigsgaard, T; Vienneau, D; Weinmayr, G; Severi, G; Fecht, D; Tjønneland, A; Leander, K; Hoek, G; Andersen, ZJ
(2021)
Long-term exposure to air pollution and liver cancer incidence in six European cohorts.
Int J Cancer, 149 (11).
pp. 1887-1897.
ISSN 1097-0215
https://doi.org/10.1002/ijc.33743
SGUL Authors: Atkinson, Richard William
Abstract
Particulate matter air pollution and diesel engine exhaust have been classified as carcinogenic for lung cancer, yet few studies have explored associations with liver cancer. We used six European adult cohorts which were recruited between 1985 and 2005, pooled within the "Effects of low-level air pollution: A study in Europe" (ELAPSE) project, and followed for the incidence of liver cancer until 2011 to 2015. The annual average exposure to nitrogen dioxide (NO2 ), particulate matter with diameter <2.5 μm (PM2.5 ), black carbon (BC), warm-season ozone (O3 ), and eight elemental components of PM2.5 (copper, iron, zinc, sulfur, nickel, vanadium, silicon, and potassium) were estimated by European-wide hybrid land-use regression models at participants' residential addresses. We analyzed the association between air pollution and liver cancer incidence by Cox proportional hazards models adjusting for potential confounders. Of 330 064 cancer-free adults at baseline, 512 developed liver cancer during a mean follow-up of 18.1 years. We observed positive linear associations between NO2 (hazard ratio, 95% confidence interval: 1.17, 1.02-1.35 per 10 μg/m3 ), PM2.5 (1.12, 0.92-1.36 per 5 μg/m3 ), and BC (1.15, 1.00-1.33 per 0.5 10-5 /m) and liver cancer incidence. Associations with NO2 and BC persisted in two-pollutant models with PM2.5 . Most components of PM2.5 were associated with the risk of liver cancer, with the strongest associations for sulfur and vanadium, which were robust to adjustment for PM2.5 or NO2 . Our study suggests that ambient air pollution may increase the risk of liver cancer, even at concentrations below current EU standards.
Item Type: |
Article
|
Additional Information: |
© 2021 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
Keywords: |
air pollution, cohort study, liver cancer incidence, particulate matter, air pollution, cohort study, liver cancer incidence, particulate matter, Oncology & Carcinogenesis, 1112 Oncology and Carcinogenesis |
SGUL Research Institute / Research Centre: |
Academic Structure > Population Health Research Institute (INPH) |
Journal or Publication Title: |
Int J Cancer |
ISSN: |
1097-0215 |
Language: |
eng |
Dates: |
Date | Event |
---|
5 October 2021 | Published | 14 August 2021 | Published Online | 16 June 2021 | Accepted |
|
Publisher License: |
Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 |
Projects: |
Project ID | Funder | Funder ID |
---|
4954-RFA14-3/16-5-3 | Health Effects Institute Research Agreement | UNSPECIFIED | NNF17OC0027812 | Novo Nordisk Foundation Challenge Programme | UNSPECIFIED |
|
PubMed ID: |
34278567 |
Web of Science ID: |
WOS:000684831700001 |
|
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/113586 |
Publisher's version: |
https://doi.org/10.1002/ijc.33743 |
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