Papadimitriou, N; Dimou, N; Gill, D; Tzoulaki, I; Murphy, N; Riboli, E; Lewis, SJ; Martin, RM; Gunter, MJ; Tsilidis, KK
(2020)
Genetically predicted circulating concentrations of micronutrients and risk of breast cancer: A Mendelian randomization study.
Int J Cancer, 148 (3).
pp. 646-653.
ISSN 1097-0215
https://doi.org/10.1002/ijc.33246
SGUL Authors: Gill, Dipender Preet Singh
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Abstract
The epidemiological literature reports inconsistent associations between consumption or circulating concentrations of micronutrients and breast cancer risk. We investigated associations between genetically predicted concentrations of 11 micronutrients (beta-carotene, calcium, copper, folate, iron, magnesium, phosphorus, selenium, vitamin B6 , vitamin B12 and zinc) and breast cancer risk using Mendelian randomization (MR). A two-sample MR study was conducted using 122 977 women with breast cancer and 105 974 controls from the Breast Cancer Association Consortium. MR analyses were conducted using the inverse variance-weighted approach, and sensitivity analyses were conducted to assess the impact of potential violations of MR assumptions. A value of 1 SD (SD: 0.08 mmol/L) higher genetically predicted concentration of magnesium was associated with a 17% (odds ratio [OR]: 1.17, 95% confidence interval [CI]: 1.10-1.25, P value = 9.1 × 10-7 ) and 20% (OR: 1.20, 95% CI: 1.08-1.34, P value = 3.2 × 10-6 ) higher risk of overall and ER+ve breast cancer, respectively. An inverse association was observed for a SD (0.5 mg/dL) higher genetically predicted phosphorus concentration and ER-ve breast cancer (OR: 0.84, 95% CI: 0.72-0.98, P value = .03). There was little evidence that any other nutrient was associated with breast cancer. The results for magnesium were robust under all sensitivity analyses and survived correction for multiple comparisons. Higher circulating concentrations of magnesium and potentially phosphorus may affect breast cancer risk. Further work is required to replicate these findings and investigate underlying mechanisms.
Item Type: |
Article
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Additional Information: |
This is the peer reviewed version of the following article: Papadimitriou, N, Dimou, N, Gill, D, et al. Genetically predicted circulating concentrations of micronutrients and risk of breast cancer: A Mendelian randomization study. Int. J. Cancer. 2021; 148: 646– 653, which has been published in final form at https://doi.org/10.1002/ijc.33246. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Keywords: |
Mendelian randomization, breast cancer, causal inference, diet, nutrition, Breast Neoplasms, Case-Control Studies, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Magnesium, Mendelian Randomization Analysis, Micronutrients, Molecular Epidemiology, Phosphorus, Polymorphism, Single Nucleotide, Receptors, Estrogen, Humans, Breast Neoplasms, Genetic Predisposition to Disease, Magnesium, Phosphorus, Micronutrients, Receptors, Estrogen, Case-Control Studies, Polymorphism, Single Nucleotide, Female, Genome-Wide Association Study, Molecular Epidemiology, Mendelian Randomization Analysis, Mendelian randomization, breast cancer, causal inference, diet, nutrition, Oncology & Carcinogenesis, 1112 Oncology and Carcinogenesis |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Int J Cancer |
ISSN: |
1097-0215 |
Language: |
eng |
Dates: |
Date | Event |
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15 December 2020 | Published | 25 August 2020 | Published Online | 27 July 2020 | Accepted |
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Publisher License: |
Publisher's own licence |
Projects: |
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PubMed ID: |
32761610 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/113529 |
Publisher's version: |
https://doi.org/10.1002/ijc.33246 |
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