Brooks, RF
(2021)
Cell Cycle Commitment and the Origins of Cell Cycle Variability.
Frontiers in Cell and Developmental Biology, 9.
p. 698066.
ISSN 2296-634X
https://doi.org/10.3389/fcell.2021.698066
SGUL Authors: Brooks, Robert Frederick
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Abstract
Exit of cells from quiescence following mitogenic stimulation is highly asynchronous, and there is a great deal of heterogeneity in the response. Even in a single, clonal population, some cells re-enter the cell cycle after a sub-optimal mitogenic signal while other, seemingly identical cells, do not, though they remain capable of responding to a higher level of stimulus. This review will consider the origins of this variability and heterogeneity, both in cells re-entering the cycle from quiescence and in the context of commitment decisions in continuously cycling populations. Particular attention will be paid to the role of two interacting molecular networks, namely the RB-E2F and APC/CCDH1 “switches.” These networks have the property of bistability and it seems likely that they are responsible for dynamic behavior previously described kinetically by Transition Probability models of the cell cycle. The relationship between these switches and the so-called Restriction Point of the cell cycle will also be considered.
Item Type: | Article | ||||||
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Additional Information: | Copyright © 2021 Brooks. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | ||||||
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) | ||||||
Journal or Publication Title: | Frontiers in Cell and Developmental Biology | ||||||
ISSN: | 2296-634X | ||||||
Dates: |
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Publisher License: | Creative Commons: Attribution 4.0 | ||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/113492 | ||||||
Publisher's version: | https://doi.org/10.3389/fcell.2021.698066 |
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