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Can Intranasal Oxytocin Reduce Craving In Automated Addictive Behaviours? A Systematic Review.

Houghton, B; Kouimtsidis, C; Duka, T; Paloyelis, Y; Bailey, A (2021) Can Intranasal Oxytocin Reduce Craving In Automated Addictive Behaviours? A Systematic Review. Br J Pharmacol, 178 (21). pp. 4316-4334. ISSN 1476-5381 https://doi.org/10.1111/bph.15617
SGUL Authors: Bailey, Alexis

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Abstract

Existing pharmacotherapies for managing craving, a strong predictor of relapse to automated addictive behaviours, are limited in efficacy and characterised by increased health risks associated with their pharmacological profile. Preclinical studies have identified oxytocin as a promising pharmacotherapy with anti-craving properties for addictive behaviours. Here, we provide the first systematic review of 17 human studies (N=722; 30% female) investigating the efficacy of intranasal oxytocin to reduce craving or consumption in addictive behaviours. We identify intranasal oxytocin as a method that warrants further investigation regarding its capacity to decrease cue-induced, acute stress-induced or withdrawal-related craving and relapse related to alcohol, cannabis, opioids, cocaine, or nicotine, including a potential role as ad-hoc medication following exposure to drug-related cues. Future studies should investigate the role of factors such as treatment regimes and sample characteristics, including the role of the amygdala, which we propose as a distinct mechanism mediating oxytocin's anti-craving properties.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Houghton, B., Kouimtsidis, C., Duka, T., Paloyelis, Y., & Bailey, A. (2021). Can intranasal oxytocin reduce craving in automated addictive behaviours? A systematic review. British Journal of Pharmacology, 1– 19, which has been published in final form at https://doi.org/10.1111/bph.15617. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Keywords: 1115 Pharmacology and Pharmaceutical Sciences, Pharmacology & Pharmacy
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE)
Journal or Publication Title: Br J Pharmacol
ISSN: 1476-5381
Language: eng
Dates:
DateEvent
19 October 2021Published
31 August 2021Published Online
28 June 2021Accepted
Publisher License: Publisher's own licence
PubMed ID: 34235724
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/113428
Publisher's version: https://doi.org/10.1111/bph.15617

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