Houghton, B; Kouimtsidis, C; Duka, T; Paloyelis, Y; Bailey, A
(2021)
Can Intranasal Oxytocin Reduce Craving In Automated Addictive Behaviours? A Systematic Review.
Br J Pharmacol, 178 (21).
pp. 4316-4334.
ISSN 1476-5381
https://doi.org/10.1111/bph.15617
SGUL Authors: Bailey, Alexis
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Abstract
Existing pharmacotherapies for managing craving, a strong predictor of relapse to automated addictive behaviours, are limited in efficacy and characterised by increased health risks associated with their pharmacological profile. Preclinical studies have identified oxytocin as a promising pharmacotherapy with anti-craving properties for addictive behaviours. Here, we provide the first systematic review of 17 human studies (N=722; 30% female) investigating the efficacy of intranasal oxytocin to reduce craving or consumption in addictive behaviours. We identify intranasal oxytocin as a method that warrants further investigation regarding its capacity to decrease cue-induced, acute stress-induced or withdrawal-related craving and relapse related to alcohol, cannabis, opioids, cocaine, or nicotine, including a potential role as ad-hoc medication following exposure to drug-related cues. Future studies should investigate the role of factors such as treatment regimes and sample characteristics, including the role of the amygdala, which we propose as a distinct mechanism mediating oxytocin's anti-craving properties.
Item Type: | Article | ||||||||
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Additional Information: | This is the peer reviewed version of the following article: Houghton, B., Kouimtsidis, C., Duka, T., Paloyelis, Y., & Bailey, A. (2021). Can intranasal oxytocin reduce craving in automated addictive behaviours? A systematic review. British Journal of Pharmacology, 1– 19, which has been published in final form at https://doi.org/10.1111/bph.15617. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | ||||||||
Keywords: | 1115 Pharmacology and Pharmaceutical Sciences, Pharmacology & Pharmacy | ||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Institute of Medical & Biomedical Education (IMBE) Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE) |
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Journal or Publication Title: | Br J Pharmacol | ||||||||
ISSN: | 1476-5381 | ||||||||
Language: | eng | ||||||||
Dates: |
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Publisher License: | Publisher's own licence | ||||||||
PubMed ID: | 34235724 | ||||||||
Go to PubMed abstract | |||||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/113428 | ||||||||
Publisher's version: | https://doi.org/10.1111/bph.15617 |
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