Scrocco, C; Bezzina, CR; Ackerman, MJ; Behr, ER
(2021)
Genetics and genomics of arrhythmic risk: current and future strategies to prevent sudden cardiac death.
Nat Rev Cardiol, 18 (11).
pp. 774-784.
ISSN 1759-5010
https://doi.org/10.1038/s41569-021-00555-y
SGUL Authors: Behr, Elijah Raphael Scrocco, Chiara
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Abstract
A genetic risk of sudden cardiac arrest and sudden death due to an arrhythmic cause, known as sudden cardiac death (SCD), has become apparent from epidemiological studies in the general population and in patients with ischaemic heart disease. However, genetic susceptibility to sudden death is greatest in young people and is associated with uncommon, monogenic forms of heart disease. Despite comprehensive pathology and genetic evaluations, SCD remains unexplained in a proportion of young people and is termed sudden arrhythmic death syndrome, which poses challenges to the identification of relatives from affected families who might be at risk of SCD. In this Review, we assess the current understanding of the epidemiology and causes of SCD and evaluate both the monogenic and the polygenic contributions to the risk of SCD in the young and SCD associated with drug therapy. Finally, we analyse the potential clinical role of genomic testing in the prevention of SCD in the general population.
Item Type: | Article | ||||||||||||
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Additional Information: | This is a post-peer-review, pre-copyedit version of an article published in Nature Reviews Cardiology. The final authenticated version is available online at: http://dx.doi.org/10.1038/s41569-021-00555-y | ||||||||||||
Keywords: | Cardiovascular System & Hematology | ||||||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) | ||||||||||||
Journal or Publication Title: | Nat Rev Cardiol | ||||||||||||
ISSN: | 1759-5010 | ||||||||||||
Language: | eng | ||||||||||||
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Publisher License: | Publisher's own licence | ||||||||||||
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PubMed ID: | 34031597 | ||||||||||||
Web of Science ID: | WOS:000653695500001 | ||||||||||||
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URI: | https://openaccess.sgul.ac.uk/id/eprint/113351 | ||||||||||||
Publisher's version: | https://doi.org/10.1038/s41569-021-00555-y |
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