Vergnano, S; Godbole, G; Simbo, A; Smith-Palmer, A; Cormican, M; Mark, A; Heath, PT
(2021)
Listeria infection in young infants: results from a national surveillance study in the UK and Ireland.
Arch Dis Child, 106 (12).
pp. 1207-1210.
ISSN 1468-2044
https://doi.org/10.1136/archdischild-2021-321602
SGUL Authors: Heath, Paul Trafford
Abstract
OBJECTIVES: To describe the epidemiology, age at infection, clinical characteristics and outcome of listeria infection in young infants to inform management and empiric antibiotic choice in young infants. DESIGN: Prospective 2-year surveillance of Listeria monocytogenes infection in young infants detected through the British Paediatric Surveillance Unit 'orange card' system and triangulated with the public health laboratories. SETTING: National population study (England, Wales, Scotland and the Ireland) PATIENTS: All infants under 90 days with proven or probable invasive listeriosis MAIN OUTCOME MEASURES: Incidence, mortality, age of infection, clinical characteristics and outcome RESULTS: During a 2-year period (2017-2019), 27 cases of listeriosis in infants <90 days of age were reported. The incidence of listeriosis in this study was 1.8 per 100 000 live births with 7% mortality (2/27). Nearly all cases presented within the first 24 hours of life (26/27). The majority (20/27, 74%) were born preterm and 16/24 (67%) were born to women from ethnic minority backgrounds. CONCLUSIONS: Invasive listeriosis in young infants in the UK and Ireland is rare and presents early in the neonatal period. National guidelines that recommend the use of amoxicillin as part of empiric regimes for sepsis and meningitis in infants over 1 month of age should be modified.
Item Type: |
Article
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Additional Information: |
This article has been accepted for publication in Archives of Disease in Childhood, 2021 following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/archdischild-2021-321602.
© Author(s) (or their employer(s)) 2021. Reuse of this manuscript version (excluding any databases, tables, diagrams, photographs and other images or illustrative material included where a another copyright owner is identified)is permitted strictly pursuant to the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC-BY-NC 4.0) http://creativecommons.org/licenses/by-nc/4.0/ |
Keywords: |
epidemiology, microbiology, neonatology, epidemiology, microbiology, neonatology, Pediatrics, 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine, 1117 Public Health and Health Services |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Arch Dis Child |
ISSN: |
1468-2044 |
Language: |
eng |
Dates: |
Date | Event |
---|
19 November 2021 | Published | 13 May 2021 | Published Online | 5 April 2021 | Accepted |
|
Publisher License: |
Creative Commons: Attribution-Noncommercial 4.0 |
PubMed ID: |
33985959 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/113300 |
Publisher's version: |
https://doi.org/10.1136/archdischild-2021-321602 |
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