Larsson, SC; Gill, D
(2021)
Genetic Evidence Supporting Fibroblast Growth Factor 21 Signalling as a Pharmacological Target for Cardiometabolic Outcomes and Alzheimer's Disease.
Nutrients, 13 (5).
p. 1504.
ISSN 2072-6643
https://doi.org/10.3390/nu13051504
SGUL Authors: Gill, Dipender Preet Singh
|
PDF
Published Version
Available under License Creative Commons Attribution. Download (3MB) | Preview |
|
![]() |
Microsoft Word (.docx)
Accepted Version
Available under License Creative Commons Attribution. Download (89MB) |
Abstract
Fibroblast growth factor 21 (FGF21) is a human metabolic hormone whose effects include modification of macronutrient preference and energy homeostasis. In animal models, FGF21 has been shown to have beneficial effects on cardiometabolic outcomes, Alzheimer's disease risk and lifespan. In this study, the single-nucleotide polymorphism rs838133 in the FGF21 gene region was leveraged to investigate the potential clinical effects of targeting FGF21. The FGF21 G allele was associated with lower intakes of total sugars and alcohol, and higher intakes of protein and fat as well as favourable with lipid levels, blood pressure traits, waist-to-hip ratio, systemic inflammation, cardiovascular outcomes, Alzheimer's disease risk and lifespan. These findings may be used to anticipate the effects of pharmacologically increasing FGF21 signalling.
Item Type: | Article | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Additional Information: | Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||||||||||||||||||
Keywords: | alcohol, cardiovascular disease, fibroblast growth factor 21, macronutrients, mendelian randomization, sugar, 1111 Nutrition and Dietetics | |||||||||||||||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) | |||||||||||||||||||||
Journal or Publication Title: | Nutrients | |||||||||||||||||||||
ISSN: | 2072-6643 | |||||||||||||||||||||
Language: | eng | |||||||||||||||||||||
Dates: |
|
|||||||||||||||||||||
Publisher License: | Creative Commons: Attribution 4.0 | |||||||||||||||||||||
Projects: |
|
|||||||||||||||||||||
PubMed ID: | 33946944 | |||||||||||||||||||||
Go to PubMed abstract | ||||||||||||||||||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/113257 | |||||||||||||||||||||
Publisher's version: | https://doi.org/10.3390/nu13051504 |
Statistics
Actions (login required)
![]() |
Edit Item |