Terranova, C; Rizzo, V; Morgante, F; Maggio, R; Calamuneri, A; Chillemi, G; Girlanda, P; Quartarone, A
(2018)
Spatial Integration of Somatosensory Inputs during Sensory-Motor Plasticity Phenomena Is Normal in Focal Hand Dystonia.
Neural Plast, 2018.
p. 4135708.
ISSN 1687-5443
https://doi.org/10.1155/2018/4135708
SGUL Authors: Morgante, Francesca
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Abstract
Background: Surround inhibition is a system that sharpens sensation by creating an inhibitory zone around the central core of activation. In the motor system, this mechanism probably contributes to the selection of voluntary movements, and it seems to be lost in dystonia. Objectives. To explore if sensory information is abnormally processed and integrated in focal hand dystonia (FHD) and if surround inhibition phenomena are operating during sensory-motor plasticity and somatosensory integration in normal humans and in patients with FHD. Methods. We looked at the MEP facilitation obtained after 5 Hz repetitive paired associative stimulation of median (PAS M), ulnar (PAS U), and median + ulnar nerve (PAS MU) stimulation in 8 normal subjects and 8 FHD. We evaluated the ratio MU/(M + U) ∗ 100 and the spatial and temporal somatosensory integration recording the somatosensory evoked potentials (SEPs) evoked by a dual nerve input. Results: FHD had two main abnormalities: first, the amount of facilitation was larger than normal subjects; second, the spatial specificity was lost. The MU/(M + U) ∗ 100 ratio was similar in healthy subjects and in FHD patients, and the somatosensory integration was normal in this subset of patients. Conclusions. The inhibitory integration of somatosensory inputs and the somatosensory inhibition are normal in patients with focal dystonia as well as lateral surrounding inhibition phenomena during sensory-motor plasticity in FHD.
Item Type: | Article | ||||||
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Additional Information: | Copyright © 2018 C. Terranova et al. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | ||||||
Keywords: | Adult, Aged, Dystonic Disorders, Evoked Potentials, Motor, Evoked Potentials, Somatosensory, Female, Humans, Male, Middle Aged, Motor Cortex, Neuronal Plasticity, Somatosensory Cortex, Transcranial Magnetic Stimulation, Motor Cortex, Somatosensory Cortex, Humans, Dystonic Disorders, Evoked Potentials, Motor, Evoked Potentials, Somatosensory, Neuronal Plasticity, Adult, Aged, Middle Aged, Female, Male, Transcranial Magnetic Stimulation, Neurology & Neurosurgery | ||||||
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) | ||||||
Journal or Publication Title: | Neural Plast | ||||||
ISSN: | 1687-5443 | ||||||
Language: | eng | ||||||
Dates: |
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Publisher License: | Creative Commons: Attribution 4.0 | ||||||
PubMed ID: | 30405710 | ||||||
Web of Science ID: | WOS:000447922400001 | ||||||
Go to PubMed abstract | |||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/113094 | ||||||
Publisher's version: | https://doi.org/10.1155/2018/4135708 |
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