Xu, L; Mondal, D; Polya, DA
(2020)
Positive Association of Cardiovascular Disease (CVD) with Chronic Exposure to Drinking Water Arsenic (As) at Concentrations below the WHO Provisional Guideline Value: A Systematic Review and Meta-Analysis.
Int J Environ Res Public Health, 17 (7).
p. 2536.
ISSN 1660-4601
https://doi.org/10.3390/ijerph17072536
SGUL Authors: Mondal, Debapriya
|
PDF
Published Version
Available under License Creative Commons Attribution. Download (2MB) | Preview |
Abstract
To the best of our knowledge, a dose-response meta-analysis of the relationship between cardiovascular disease (CVD) and arsenic (As) exposure at drinking water As concentrations lower than the WHO provisional guideline value (10 µg/L) has not been published yet. We conducted a systematic review and meta-analyses to estimate the pooled association between the relative risk of each CVD endpoint and low-level As concentration in drinking water both linearly and non-linearly using a random effects dose-response model. In this study, a significant positive association was found between the risks of most CVD outcomes and drinking water As concentration for both linear and non-linear models (p-value for trend < 0.05). Using the preferred linear model, we found significant increased risks of coronary heart disease (CHD) mortality and CVD mortality as well as combined fatal and non-fatal CHD, CVD, carotid atherosclerosis disease and hypertension in those exposed to drinking water with an As concentration of 10 µg/L compared to the referent (drinking water As concentration of 1 µg/L) population. Notwithstanding limitations included, the observed significant increased risks of CVD endpoints arising from As concentrations in drinking water between 1 µg/L and the 10 µg/L suggests further lowering of this guideline value should be considered.
Item Type: | Article | ||||||
---|---|---|---|---|---|---|---|
Additional Information: | Correction available at https://doi.org/10.3390/ijerph17238947 | http://openaccess.sgul.ac.uk/id/eprint/113078/ © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | ||||||
Keywords: | arsenic, cardiovascular disease, dose-response, low level, meta-analysis, systematic review, Arsenic, Atherosclerosis, Cardiovascular Diseases, Coronary Disease, Drinking Water, Humans, Hypertension, Water Pollutants, Chemical, Humans, Cardiovascular Diseases, Coronary Disease, Hypertension, Arsenic, Water Pollutants, Chemical, Atherosclerosis, Drinking Water, arsenic, low level, cardiovascular disease, dose-response, systematic review, meta-analysis, MD Multidisciplinary, Toxicology | ||||||
SGUL Research Institute / Research Centre: | Academic Structure > Institute of Medical & Biomedical Education (IMBE) Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE ) |
||||||
Journal or Publication Title: | Int J Environ Res Public Health | ||||||
ISSN: | 1660-4601 | ||||||
Language: | eng | ||||||
Dates: |
|
||||||
Publisher License: | Creative Commons: Attribution 4.0 | ||||||
PubMed ID: | 32272785 | ||||||
Web of Science ID: | WOS:000530763300368 | ||||||
Go to PubMed abstract | |||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/113087 | ||||||
Publisher's version: | https://doi.org/10.3390/ijerph17072536 |
Statistics
Actions (login required)
![]() |
Edit Item |