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Guidelines for performing Mendelian randomization investigations: update for summer 2023.

Burgess, S; Davey Smith, G; Davies, NM; Dudbridge, F; Gill, D; Glymour, MM; Hartwig, FP; Kutalik, Z; Holmes, MV; Minelli, C; et al. Burgess, S; Davey Smith, G; Davies, NM; Dudbridge, F; Gill, D; Glymour, MM; Hartwig, FP; Kutalik, Z; Holmes, MV; Minelli, C; Morrison, JV; Pan, W; Relton, CL; Theodoratou, E (2023) Guidelines for performing Mendelian randomization investigations: update for summer 2023. Wellcome Open Res, 4. p. 186. ISSN 2398-502X https://doi.org/10.12688/wellcomeopenres.15555.3
SGUL Authors: Gill, Dipender Preet Singh

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Abstract

This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into ten sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), extensions and additional analyses, data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 24 months.

Item Type: Article
Additional Information: © 2023 Burgess S et al. This is an open access work distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Mendelian randomization, causal inference, genetic epidemiology, guidelines, Mendelian randomization, causal inference, genetic epidemiology, guidelines
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Wellcome Open Res
ISSN: 2398-502X
Language: eng
Dates:
DateEvent
4 August 2023Published
19 July 2023Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
U01 AG073079NIA NIH HHSUNSPECIFIED
MC_UU_00011/5Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MC_UU_12013/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
FS/18/23/33512British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
MC_UU_12013/9Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
RF1 AG067924NIA NIH HHSUNSPECIFIED
MC_UU_00002/7Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
204623/Z/16/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
225790/Z/22/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
MC_UU_00011/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
204623Wellcome Trusthttp://dx.doi.org/10.13039/100004440
R01 AG065636NIA NIH HHSUNSPECIFIED
C31250/A22804Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
ES/N000757/1Economic and Social Research Councilhttp://dx.doi.org/10.13039/501100000269
NIHR203312National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
PubMed ID: 32760811
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/112803
Publisher's version: https://doi.org/10.12688/wellcomeopenres.15555.3

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