Burgess, S;
Davey Smith, G;
Davies, NM;
Dudbridge, F;
Gill, D;
Glymour, MM;
Hartwig, FP;
Kutalik, Z;
Holmes, MV;
Minelli, C;
et al.
Burgess, S; Davey Smith, G; Davies, NM; Dudbridge, F; Gill, D; Glymour, MM; Hartwig, FP; Kutalik, Z; Holmes, MV; Minelli, C; Morrison, JV; Pan, W; Relton, CL; Theodoratou, E
(2023)
Guidelines for performing Mendelian randomization investigations: update for summer 2023.
Wellcome Open Res, 4.
p. 186.
ISSN 2398-502X
https://doi.org/10.12688/wellcomeopenres.15555.3
SGUL Authors: Gill, Dipender Preet Singh
Abstract
This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into ten sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), extensions and additional analyses, data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 24 months.
Item Type: |
Article
|
Additional Information: |
© 2023 Burgess S et al. This is an open access work distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: |
Mendelian randomization, causal inference, genetic epidemiology, guidelines, Mendelian randomization, causal inference, genetic epidemiology, guidelines |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Wellcome Open Res |
ISSN: |
2398-502X |
Language: |
eng |
Dates: |
Date | Event |
---|
4 August 2023 | Published | 19 July 2023 | Accepted |
|
Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
|
PubMed ID: |
32760811 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/112803 |
Publisher's version: |
https://doi.org/10.12688/wellcomeopenres.15555.3 |
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