Ben-Haim, Y; Asimaki, A; Behr, ER
(2021)
Brugada syndrome and arrhythmogenic cardiomyopathy: overlapping disorders of the connexome?
Europace, 23 (5).
pp. 653-664.
ISSN 1532-2092
https://doi.org/10.1093/europace/euaa277
SGUL Authors: Asimaki, Angeliki Behr, Elijah Raphael
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Abstract
Arrhythmogenic cardiomyopathy (ACM) and Brugada syndrome (BrS) are inherited diseases characterized by an increased risk for arrhythmias and sudden cardiac death. Possible overlap between the two was suggested soon after the description of BrS. Since then, various studies focusing on different aspects have been published pointing to similar findings in the two diseases. More recent findings on the structure of the cardiac cell-cell junctions may unite the pathophysiology of both diseases and give further evidence to the theory that they may in part be variants of the same disease spectrum. In this review, we aim to summarize the studies indicating the pathophysiological, genetic, structural, and electrophysiological overlap between ACM and BrS.
Item Type: |
Article
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Additional Information: |
This is a pre-copyedited, author-produced version of an article accepted for publication in EP Europace following peer review. The version of record Yael Ben-Haim, Angeliki Asimaki, Elijah R Behr, Brugada syndrome and arrhythmogenic cardiomyopathy: overlapping disorders of the connexome?, EP Europace, Volume 23, Issue 5, May 2021, Pages 653–664 is available online at: https://doi.org/10.1093/europace/euaa277 |
Keywords: |
Arrhythmogenic cardiomyopathy Brugada syndrome Genetics Connexome, Arrhythmogenic cardiomyopathy Brugada syndrome Genetics Connexome, 1103 Clinical Sciences, Cardiovascular System & Hematology |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: |
Europace |
ISSN: |
1532-2092 |
Language: |
eng |
Dates: |
Date | Event |
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May 2021 | Published | 17 November 2020 | Published Online | 19 August 2020 | Accepted |
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Publisher License: |
Publisher's own licence |
PubMed ID: |
33200179 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/112644 |
Publisher's version: |
https://doi.org/10.1093/europace/euaa277 |
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