Augustin, Y; Staines, HM; Krishna, S
(2020)
Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing.
Pharmacol Ther, 216.
p. 107706.
ISSN 1879-016X
https://doi.org/10.1016/j.pharmthera.2020.107706
SGUL Authors: Augustin, Yolanda Sydney Krishna, Sanjeev Staines, Henry Michael
Abstract
Artemisinins are a unique class of antimalarial drugs with significant potential for drug repurposing for a wide range of diseases including cancer. Cancer is a leading cause of death globally and the majority of cancer related deaths occur in Low and Middle Income Countries (LMICs) where conventional treatment options are often limited by financial cost. Drug repurposing can significantly shorten new therapeutic discovery pathways, ensuring greater accessibility and affordability globally. Artemisinins have an excellent safety and tolerability profile as well as being affordable for deployment in Low and Middle Class Income Countries at around USD1 per daily dose. Robust, well designed clinical trials of artemisinin drug repurposing are indicated for a variety of different cancers and treatment settings.
Item Type: |
Article
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Additional Information: |
© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Keywords: |
Anti-cancer therapy, Artemisinins, Artesunate, Cancer, Drug repurposing, Oncology, Anti-cancer therapy, Artemisinins, Artesunate, Cancer, Drug repurposing, Oncology, Pharmacology & Pharmacy, 1115 Pharmacology and Pharmaceutical Sciences |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Pharmacol Ther |
ISSN: |
1879-016X |
Language: |
eng |
Dates: |
Date | Event |
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December 2020 | Published | 16 October 2020 | Published Online | 13 October 2020 | Accepted |
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Publisher License: |
Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 |
Projects: |
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PubMed ID: |
33075360 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/112575 |
Publisher's version: |
https://doi.org/10.1016/j.pharmthera.2020.107706 |
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