SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Repurposing Antimalarials to Tackle the COVID-19 Pandemic.

Krishna, S; Augustin, Y; Wang, J; Xu, C; Staines, HM; Platteeuw, H; Kamarulzaman, A; Sall, A; Kremsner, P (2021) Repurposing Antimalarials to Tackle the COVID-19 Pandemic. Trends Parasitol, 37 (1). pp. 8-11. ISSN 1471-5007 https://doi.org/10.1016/j.pt.2020.10.003
SGUL Authors: Staines, Henry Michael Augustin, Yolanda Sydney Krishna, Sanjeev

[img] Microsoft Word (.docx) Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.
Download (90kB)

Abstract

Artemisinin-based combination therapies (ACTs) have demonstrated in vitro inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Artemisinins have also shown anti-inflammatory effects, including inhibition of interleukin-6 (IL-6) that plays a key role in the development of severe coronavirus disease 2019 (COVID-19). There is now sufficient evidence for the effectiveness of ACTs, and in particular artesunate/pyronaridine, to support clinical studies for COVID-19 infections.

Item Type: Article
Additional Information: © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ Correction available at https://doi.org/10.1016/j.pt.2020.12.009
Keywords: SARS-CoV-2, antimalarial, antiviral, artesunate/pyronaridine, cytokine storm, drug repurposing, 06 Biological Sciences, 07 Agricultural and Veterinary Sciences, 11 Medical and Health Sciences, Mycology & Parasitology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Trends Parasitol
ISSN: 1471-5007
Language: eng
Dates:
DateEvent
January 2021Published
19 October 2020Published Online
12 October 2020Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Projects:
Project IDFunderFunder ID
204809/Z/16/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
PubMed ID: 33153922
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/112574
Publisher's version: https://doi.org/10.1016/j.pt.2020.10.003

Statistics

Item downloaded times since 01 Dec 2020.

Actions (login required)

Edit Item Edit Item