Graham, NSN;
Junghans, C;
Downes, R;
Sendall, C;
Lai, H;
McKirdy, A;
Elliott, P;
Howard, R;
Wingfield, D;
Priestman, M;
et al.
Graham, NSN; Junghans, C; Downes, R; Sendall, C; Lai, H; McKirdy, A; Elliott, P; Howard, R; Wingfield, D; Priestman, M; Ciechonska, M; Cameron, L; Storch, M; Crone, MA; Freemont, PS; Randell, P; McLaren, R; Lang, N; Ladhani, S; Sanderson, F; Sharp, DJ
(2020)
SARS-CoV-2 infection, clinical features and outcome of COVID-19 in United Kingdom nursing homes.
J Infect, 81 (3).
pp. 411-419.
ISSN 1532-2742
https://doi.org/10.1016/j.jinf.2020.05.073
SGUL Authors: Ladhani, Shamez Nizarali
Abstract
OBJECTIVES: To understand SARS-Co-V-2 infection and transmission in UK nursing homes in order to develop preventive strategies for protecting the frail elderly residents. METHODS: An outbreak investigation involving 394 residents and 70 staff, was carried out in 4 nursing homes affected by COVID-19 outbreaks in central London. Two point-prevalence surveys were performed one week apart where residents underwent SARS-CoV-2 testing and had relevant symptoms documented. Asymptomatic staff from three of the four homes were also offered SARS-CoV-2 testing. RESULTS: Overall, 26% (95% CI 22-31) of residents died over the two-month period. All-cause mortality increased by 203% (95% CI 70-336) compared with previous years. Systematic testing identified 40% (95% CI 35-46) of residents as positive for SARS-CoV-2, and of these 43% (95% CI 34-52) were asymptomatic and 18% (95% CI 11-24) had only atypical symptoms; 4% (95% CI -1 to 9) of asymptomatic staff also tested positive. CONCLUSIONS: The SARS-CoV-2 outbreak in four UK nursing homes was associated with very high infection and mortality rates. Many residents developed either atypical or had no discernible symptoms. A number of asymptomatic staff members also tested positive, suggesting a role for regular screening of both residents and staff in mitigating future outbreaks.
Item Type: |
Article
|
Additional Information: |
© 2020 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0/) |
Keywords: |
COVID-19, Care home, Coronavirus, Diagnostic testing, Nursing home, SARS-CoV-2, Aged, Aged, 80 and over, Betacoronavirus, Clinical Laboratory Techniques, Coronavirus Infections, Female, Humans, Male, Nursing Homes, Pandemics, Pneumonia, Viral, Time Factors, United Kingdom, Humans, Pneumonia, Viral, Coronavirus Infections, Clinical Laboratory Techniques, Time Factors, Aged, Aged, 80 and over, Nursing Homes, Female, Male, Pandemics, United Kingdom, Betacoronavirus, 1103 Clinical Sciences, Microbiology |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
J Infect |
ISSN: |
1532-2742 |
Language: |
eng |
Dates: |
Date | Event |
---|
September 2020 | Published | 3 June 2020 | Published Online | 30 May 2020 | Accepted |
|
Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
|
PubMed ID: |
32504743 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/112481 |
Publisher's version: |
https://doi.org/10.1016/j.jinf.2020.05.073 |
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