Singanayagam, A; Patel, M; Charlett, A; Lopez Bernal, J; Saliba, V; Ellis, J; Ladhani, S; Zambon, M; Gopal, R
(2020)
Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020.
Euro Surveill, 25 (32).
ISSN 1560-7917
https://doi.org/10.2807/1560-7917.ES.2020.25.32.2001483
SGUL Authors: Ladhani, Shamez Nizarali
Abstract
Severe acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate coronavirus disease (n = 324 samples analysed). RT-PCR cycle threshold (Ct) values correlate strongly with cultivable virus. Probability of culturing virus declines to 8% in samples with Ct > 35 and to 6% 10 days after onset; it is similar in asymptomatic and symptomatic persons. Asymptomatic persons represent a source of transmissible virus.
| Item Type: |
Article
|
| Additional Information: |
This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence and indicate if changes were made. Any supplementary material referenced in the article can be found in the online version. This article is copyright of the authors or their affiliated in-stitutions, 2020. |
| Keywords: |
COVID-19, SARS-CoV-2, coronavirus, infectiousness, public health policy, respiratory virus, Antibodies, Viral, Asymptomatic Infections, Betacoronavirus, Clinical Laboratory Techniques, Coronavirus, Coronavirus Infections, England, Humans, Pandemics, Pneumonia, Viral, RNA, Viral, Reverse Transcriptase Polymerase Chain Reaction, Serologic Tests, Viral Load, Virus Shedding, Humans, Coronavirus, Pneumonia, Viral, Coronavirus Infections, RNA, Viral, Antibodies, Viral, Serologic Tests, Clinical Laboratory Techniques, Viral Load, Reverse Transcriptase Polymerase Chain Reaction, Virus Shedding, England, Asymptomatic Infections, Pandemics, Betacoronavirus |
| SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
| Journal or Publication Title: |
Euro Surveill |
| ISSN: |
1560-7917 |
| Language: |
eng |
| Dates: |
| Date | Event |
|---|
| 13 August 2020 | Published | | 12 August 2020 | Accepted |
|
| Publisher License: |
Creative Commons: Attribution 4.0 |
| PubMed ID: |
32794447 |
| Web of Science ID: |
WOS:000563781500001 |
 |
Go to PubMed abstract |
| URI: |
https://openaccess.sgul.ac.uk/id/eprint/112477 |
| Publisher's version: |
https://doi.org/10.2807/1560-7917.ES.2020.25.32.2001483 |
Statistics
Item downloaded times since 09 Oct 2020.
Actions (login required)
 |
Edit Item |
