Linsell, L; Johnson, S; Wolke, D; O'Reilly, H; Morris, JK; Kurinczuk, JJ; Marlow, N
(2018)
Cognitive trajectories from infancy to early adulthood following birth before 26 weeks of gestation: a prospective, population-based cohort study.
Arch Dis Child, 103 (4).
pp. 363-370.
ISSN 1468-2044
https://doi.org/10.1136/archdischild-2017-313414
SGUL Authors: Morris, Joan Katherine
Abstract
OBJECTIVE: To determine the trajectory of cognitive test scores from infancy to adulthood in individuals born extremely preterm compared with term-born individuals. DESIGN: A prospective, population-based cohort study. SETTING: 276 maternity units in the UK and Ireland. PATIENTS: 315 surviving infants born less than 26 completed weeks of gestation recruited at birth in 1995 and 160 term-born classroom controls recruited at age 6. MAIN OUTCOME MEASURES: Bayley Scales of Infant Development-Second Edition (age 2.5); Kaufman Assessment Battery for Children (ages 6/11); Wechsler Abbreviated Scale of Intelligence-Second Edition (age 19). RESULTS: The mean cognitive scores of extremely preterm individuals over the period were on average 25.2 points below their term-born peers (95% CI -27.8 to -22.6) and remained significantly lower at every assessment. Cognitive trajectories in term-born boys and girls did not differ significantly, but the scores of extremely preterm boys were on average 8.8 points below those of extremely preterm girls (95% CI -13.6 to -4.0). Higher maternal education elevated scores in both groups by 3.2 points (95% CI 0.8 to 5.7). Within the extremely preterm group, moderate/severe neonatal brain injury (mean difference: -10.9, 95% CI -15.5 to -6.3) and gestational age less than 25 weeks (mean difference: -4.4, 95% CI -8.4 to -0.4) also had an adverse impact on cognitive function. CONCLUSIONS: There is no evidence that impaired cognitive function in extremely preterm individuals materially recovers or deteriorates from infancy through to 19 years. Cognitive test scores in infancy and early childhood reflect early adult outcomes.
Item Type: |
Article
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Additional Information: |
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/ |
Keywords: |
epidemiology, neonatology, neurodevelopment, Adolescent, Case-Control Studies, Child, Child, Preschool, Cognition, Cognition Disorders, Female, Follow-Up Studies, Human Development, Humans, Infant, Infant, Extremely Premature, Infant, Newborn, Infant, Premature, Diseases, Intelligence Tests, Male, Neuropsychological Tests, Prognosis, Prospective Studies, Risk Factors, Young Adult, Humans, Infant, Premature, Diseases, Prognosis, Risk Factors, Case-Control Studies, Follow-Up Studies, Prospective Studies, Human Development, Cognition, Cognition Disorders, Intelligence Tests, Neuropsychological Tests, Adolescent, Child, Child, Preschool, Infant, Infant, Newborn, Female, Male, Young Adult, Infant, Extremely Premature, epidemiology, neonatology, neurodevelopment, Pediatrics, 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine, 1117 Public Health and Health Services |
SGUL Research Institute / Research Centre: |
Academic Structure > Population Health Research Institute (INPH) |
Journal or Publication Title: |
Arch Dis Child |
ISSN: |
1468-2044 |
Language: |
eng |
Dates: |
Date | Event |
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21 March 2018 | Published | 16 November 2017 | Published Online | 18 September 2017 | Accepted |
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Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
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PubMed ID: |
29146572 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/112459 |
Publisher's version: |
https://doi.org/10.1136/archdischild-2017-313414 |
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