Gilani, A; Ramsay, SE; Welsh, P; Papacosta, O; Lennon, LT; Whincup, PH; Wannamethee, SG
(2021)
Vitamin D deficiency is associated with orthostatic hypotension in older men: a cross-sectional analysis from the British Regional Heart Study.
Age Ageing, 50 (1).
pp. 198-204.
ISSN 1468-2834
https://doi.org/10.1093/ageing/afaa146
SGUL Authors: Whincup, Peter Hynes
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Abstract
BACKGROUND: orthostatic hypotension (OH) that occurs within, or at, 1 minute of standing is associated with higher risk of falls, myocardial infarction, syncope and mortality, compared to OH that occurs after 1 minute of standing. Whether vitamin D deficiency increases the risk of OH is controversial. METHODS: this was a cross-sectional analysis of 3,620 older, community-dwelling men. Multinomial, multiple logistic regression models were used to calculate the risk of OH across categories of vitamin D status (deficient [<25 nmol/l], insufficient [≥25-<50 nmol/l] and sufficient [≥50 nmol/l]) and parathyroid hormone quintile. RESULTS: men with vitamin D deficiency were more likely to have OH that occurred within 1 minute of standing in univariate logistic regression (OR 1.88, 95% CI 1.40-2.53) and multinomial, multiple logistic regression (OR 1.51, 95% CI 1.06-2.15), compared to men with sufficient levels of vitamin D. Vitamin D insufficiency was not associated with the risk of OH. Elevated parathyroid hormone was not associated with risk of OH. CONCLUSION: the absence of an association between vitamin D insufficiency and risk of OH and the presence of an association between vitamin D deficiency and risk of OH suggest that there may be a threshold effect; it is only below a particular level of vitamin D that risk of OH is increased. In this cohort, the threshold was <25 nmol/l. Future work should investigate whether treating vitamin D deficiency can improve postural blood pressure or if preventing vitamin D deficiency reduces the incidence of OH.
Item Type: | Article | ||||||
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Additional Information: | © The Author(s) 2020. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | ||||||
Keywords: | epidemiology, geriatrics, older people, orthostatic hypotension, vitamin D, Geriatrics, 1103 Clinical Sciences, 1701 Psychology, 1117 Public Health and Health Services | ||||||
SGUL Research Institute / Research Centre: | Academic Structure > Population Health Research Institute (INPH) | ||||||
Journal or Publication Title: | Age Ageing | ||||||
ISSN: | 1468-2834 | ||||||
Language: | eng | ||||||
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Publisher License: | Creative Commons: Attribution-Noncommercial 4.0 | ||||||
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PubMed ID: | 32902636 | ||||||
Go to PubMed abstract | |||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/112421 | ||||||
Publisher's version: | https://doi.org/10.1093/ageing/afaa146 |
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