Hardy, CJD;
Agustus, JL;
Marshall, CR;
Clark, CN;
Russell, LL;
Bond, RL;
Brotherhood, EV;
Thomas, DL;
Crutch, SJ;
Rohrer, JD;
et al.
Hardy, CJD; Agustus, JL; Marshall, CR; Clark, CN; Russell, LL; Bond, RL; Brotherhood, EV; Thomas, DL; Crutch, SJ; Rohrer, JD; Warren, JD
(2017)
Behavioural and neuroanatomical correlates of auditory speech analysis in primary progressive aphasias.
Alzheimer's Research & Therapy, 9 (1).
p. 53.
ISSN 1758-9193
https://doi.org/10.1186/s13195-017-0278-2
SGUL Authors: Clark, Camilla Neegaard
Abstract
Background
Non-verbal auditory impairment is increasingly recognised in the primary progressive aphasias (PPAs) but its relationship to speech processing and brain substrates has not been defined. Here we addressed these issues in patients representing the non-fluent variant (nfvPPA) and semantic variant (svPPA) syndromes of PPA.
Methods
We studied 19 patients with PPA in relation to 19 healthy older individuals. We manipulated three key auditory parameters—temporal regularity, phonemic spectral structure and prosodic predictability (an index of fundamental information content, or entropy)—in sequences of spoken syllables. The ability of participants to process these parameters was assessed using two-alternative, forced-choice tasks and neuroanatomical associations of task performance were assessed using voxel-based morphometry of patients’ brain magnetic resonance images.
Results
Relative to healthy controls, both the nfvPPA and svPPA groups had impaired processing of phonemic spectral structure and signal predictability while the nfvPPA group additionally had impaired processing of temporal regularity in speech signals. Task performance correlated with standard disease severity and neurolinguistic measures. Across the patient cohort, performance on the temporal regularity task was associated with grey matter in the left supplementary motor area and right caudate, performance on the phoneme processing task was associated with grey matter in the left supramarginal gyrus, and performance on the prosodic predictability task was associated with grey matter in the right putamen.
Conclusions
Our findings suggest that PPA syndromes may be underpinned by more generic deficits of auditory signal analysis, with a distributed cortico-subcortical neuraoanatomical substrate extending beyond the canonical language network. This has implications for syndrome classification and biomarker development.
Item Type: |
Article
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Additional Information: |
© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link tothe Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
Keywords: |
11 Medical and Health Sciences |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: |
Alzheimer's Research & Therapy |
ISSN: |
1758-9193 |
Language: |
en |
Dates: |
Date | Event |
---|
27 July 2017 | Published | 16 June 2017 | Accepted |
|
Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
|
URI: |
https://openaccess.sgul.ac.uk/id/eprint/112256 |
Publisher's version: |
https://doi.org/10.1186/s13195-017-0278-2 |
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