Li, G; Jackson, C; Bielicki, J; Ellis, S; Hsia, Y; Sharland, M
(2020)
Global sales of oral antibiotics formulated for children.
Bull World Health Organ, 98 (7).
pp. 458-466.
ISSN 1564-0604
https://doi.org/10.2471/BLT.19.235309
SGUL Authors: Sharland, Michael Roy
Abstract
Objective: To investigate international consumption patterns of child-appropriate oral formulations of antibiotics by formulation type, with a focus on dispersible tablets, using data from a global sales database. Method: Antibiotic sales data for 2015 covering 74 countries and regional country groups were obtained from the MIDAS® pharmaceutical sales database, which includes samples of pharmacy wholesalers and retailers. The focus was on sales of child-appropriate oral formulations of Access antibiotics in the 2017 World Health Organization's WHO Model list of essential medicines for children. Sales volumes are expressed using a standard unit (i.e. one tablet, capsule, ampoule or vial or 5 mL of liquid). Sales were analysed by antibiotic, WHO region and antibiotic formulation. Findings: Globally, 17.7 billion standard units of child-appropriate oral antibiotic formulations were sold in 2015, representing 24% of total antibiotic sales of 74.4 billion units (both oral and parenteral) in the database. The top five child-appropriate Access antibiotics by sales volume were amoxicillin, amoxicillin with clavulanic acid, trimethoprim-sulfamethoxazole, cefalexin and ampicillin. The proportion of the top five sold for use as a syrup varied between 42% and 99%. Dispersible tablets represented only 22% of all child-appropriate oral formulation sales and made up only 15% of sales of 10 selected Access antibiotics on the model list for children. Conclusion: Globally most child-appropriate oral antibiotics were not sold as dispersible tablets in 2015, as recommended by WHO. There is a clear need for novel solid forms of antibiotics suitable for use in children.
Item Type: |
Article
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Additional Information: |
© 2020 Grace Li, Charlotte Jackson, Julia Bielicki, Sally Ellis, Yingfen Hsia & Mike Sharland; licensee the World Health Organization. This is an open access article distributed under the terms of the Creative Commons Attribution IGO License (http://creativecommons.org/licenses/by/3.0/igo/legalcode), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In any reproduction of this article there should not be any suggestion that WHO or this article endorse any specific organization, products or services. The use of the WHO logo is not permitted. This notice should be preserved along with the article's original URL. |
Keywords: |
11 Medical and Health Sciences, Tropical Medicine |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Bull World Health Organ |
ISSN: |
1564-0604 |
Language: |
eng |
Dates: |
Date | Event |
---|
1 July 2020 | Published | 8 May 2020 | Published Online | 3 April 2020 | Accepted |
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Publisher License: |
Creative Commons: Attribution 3.0 |
PubMed ID: |
32742031 |
Web of Science ID: |
WOS:000548179800006 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/112230 |
Publisher's version: |
https://doi.org/10.2471/BLT.19.235309 |
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