Germont, Z; Bidet, P; Plainvert, C; Bonacorsi, S; Poyart, C; Biran, V; Frérot, A; Faye, A; Basmaci, R
(2020)
Invasive Streptococcus pyogenes Infections in <3-Month-Old Infants in France: Clinical and Laboratory Features.
Front Pediatr, 8.
p. 204.
ISSN 2296-2360
https://doi.org/10.3389/fped.2020.00204
SGUL Authors: Basmaci, Romain
Abstract
Few data are available on invasive group A Streptococcus (GAS) infections (IGASIs) in infants. We described initial clinical and laboratory features and outcomes of <3-month-old infants hospitalized for an IGASI between 2007 and 2016 in France. Patients were identified from the French National Reference Centre for streptococci. IGASI was defined by the isolation of GAS from blood cultures or from other usually sterile sites. Data collection was performed by assessing the patients' hospitalization reports. Twenty-six patients (15 males; 57.7%) were included. Among 19 cases with available data, 14 (73.7%) were household contacts of a GAS infection, reaching 8/9 (88.9%) in neonates. The diagnoses were bacteremia (n = 18; 69.2%), pleural effusion or pneumonia (n = 6; 23.1%), meningitis with brain abscess (n = 1; 3.8%), and septic arthritis (n = 1; 3.8%). Fever (n = 10; 38.5%), hemodynamic disorders (n = 11; 42.3%), respiratory disorders (n = 7; 26.9%), thrombocytopenia (n = 7; 26.9%), and neutropenia (n = 5; 19.2%) were frequently observed. The main emm-genotype was emm-1 (n = 8; 30.8%). Thirteen (50.0%) infants have been admitted to the intensive care unit, and two (7.7%) died. Respiratory disorders, high C-reactive protein level, and the need for transfusion were significantly associated with severity. IGASI remains uncommon in <3-month-old children but leads to a high morbidity. Whether an antibiotic prophylaxis for contact neonates of a patient with GAS infection decreases the risk of infection remains to be determined.
Item Type: |
Article
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Additional Information: |
Copyright © 2020 Germont, Bidet, Plainvert, Bonacorsi, Poyart, Biran, Frérot, Faye and Basmaci. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
Keywords: |
children, group A Streptococcus, invasive infection, neonatal infection, prophylaxis, group A Streptococcus, invasive infection, children, neonatal infection, prophylaxis |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Front Pediatr |
ISSN: |
2296-2360 |
Language: |
eng |
Dates: |
Date | Event |
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6 May 2020 | Published | 3 April 2020 | Accepted |
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Publisher License: |
Creative Commons: Attribution 4.0 |
PubMed ID: |
32435626 |
Web of Science ID: |
WOS:000536654000001 |
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Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/112196 |
Publisher's version: |
https://doi.org/10.3389/fped.2020.00204 |
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