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Hypomimia in Parkinson's disease: an axial sign responsive to levodopa.

Ricciardi, L; De Angelis, A; Marsili, L; Faiman, I; Pradhan, P; Pereira, EA; Edwards, MJ; Morgante, F; Bologna, M (2020) Hypomimia in Parkinson's disease: an axial sign responsive to levodopa. Eur J Neurol, 27 (12). pp. 2422-2429. ISSN 1468-1331 https://doi.org/10.1111/ene.14452
SGUL Authors: Morgante, Francesca Pereira, Erlick Abilio Coelho Edwards, Mark John James

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Abstract

BACKGROUND AND PURPOSE: Hypomimia is a prominent clinical feature in people with Parkinson's disease (PD), but it remains under-investigated. We aimed to examine the clinical correlates of hypomimia in PD and to determine whether this is a levodopa-responsive sign. METHODS: We included 89 people with PD. Hypomimia was assessed from digital video recordings by movement disorder specialists. Clinical evaluation included use of the Unified Parkinson's Disease Rating Scale part III (UPDRS-III), and assessment of motor and non-motor symptoms using standardized clinical scales. The relationships between hypomimia and other clinical data were analysed using Mann-Whitney U-tests and regression analysis. RESULTS: Hypomimia occurred in up to 70% of patients with PD. Patients with hypomimia had worse UPDRS-III 'off-medication' scores, mainly driven by bradykinesia and rigidity subscores. Patients with hypomimia also had worse apathy than patients without hypomimia. Finally, we found that hypomimia was levodopa-responsive and its improvement mirrored the change by levodopa in axial motor symptoms. CONCLUSION: Our study provides novel information regarding the clinical correlates of hypomimia in people with PD. A better understanding of hypomimia may be relevant for improving treatment and quality of life in PD.

Item Type: Article
Additional Information: © 2020 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Keywords: Parkinson’s disease, face, facial bradykinesia, hypomimia, non-motor symptoms, face, facial bradykinesia, hypomimia, non-motor symptoms, Parkinson's disease, Neurology & Neurosurgery, 1103 Clinical Sciences, 1109 Neurosciences
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Eur J Neurol
ISSN: 1468-1331
Language: eng
Dates:
DateEvent
8 November 2020Published
20 August 2020Published Online
19 July 2020Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
PubMed ID: 32702196
Web of Science ID: WOS:000560731100001
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/112165
Publisher's version: https://doi.org/10.1111/ene.14452

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