Sande, CJ;
Njunge, JM;
Mwongeli Ngoi, J;
Mutunga, MN;
Chege, T;
Gicheru, ET;
Gardiner, EM;
Gwela, A;
Green, CA;
Drysdale, SB;
et al.
Sande, CJ; Njunge, JM; Mwongeli Ngoi, J; Mutunga, MN; Chege, T; Gicheru, ET; Gardiner, EM; Gwela, A; Green, CA; Drysdale, SB; Berkley, JA; Nokes, DJ; Pollard, AJ
(2019)
Airway response to respiratory syncytial virus has incidental antibacterial effects.
Nat Commun, 10 (1).
p. 2218.
ISSN 2041-1723
https://doi.org/10.1038/s41467-019-10222-z
SGUL Authors: Drysdale, Simon Bruce
Abstract
RSV infection is typically associated with secondary bacterial infection. We hypothesise that the local airway immune response to RSV has incidental antibacterial effects. Using coordinated proteomics and metagenomics analysis we simultaneously analysed the microbiota and proteomes of the upper airway and determined direct antibacterial activity in airway secretions of RSV-infected children. Here, we report that the airway abundance of Streptococcus was higher in samples collected at the time of RSV infection compared with samples collected one month later. RSV infection is associated with neutrophil influx into the airway and degranulation and is marked by overexpression of proteins with known antibacterial activity including BPI, EPX, MPO and AZU1. Airway secretions of children infected with RSV, have significantly greater antibacterial activity compared to RSV-negative controls. This RSV-associated, neutrophil-mediated antibacterial response in the airway appears to act as a regulatory mechanism that modulates bacterial growth in the airways of RSV-infected children.
Item Type: |
Article
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Additional Information: |
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly fromthe copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
© The Author(s) 2019
Correction available at https://doi.org/10.1038/s41467-019-11222-9 |
Keywords: |
Bacterial Infections, Cell Degranulation, Child, Preschool, Humans, Infant, Infant, Newborn, Kenya, Metagenomics, Microbiota, Neutrophils, Proteomics, Respiratory Mucosa, Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus, Human, Streptococcus, Respiratory Mucosa, Neutrophils, Humans, Streptococcus, Respiratory Syncytial Virus, Human, Bacterial Infections, Respiratory Syncytial Virus Infections, Proteomics, Cell Degranulation, Child, Preschool, Infant, Infant, Newborn, Kenya, Metagenomics, Microbiota, MD Multidisciplinary |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Nat Commun |
ISSN: |
2041-1723 |
Language: |
eng |
Dates: |
Date | Event |
---|
17 May 2019 | Published | 26 April 2019 | Accepted |
|
Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
|
PubMed ID: |
31101811 |
Web of Science ID: |
WOS:000468174600018 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/112160 |
Publisher's version: |
https://doi.org/10.1038/s41467-019-10222-z |
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