De Wolf, HA;
Langlois, MR;
Suvisaari, J;
Aakre, KM;
Baum, H;
Collinson, P;
Duff, CJ;
Gruson, D;
Hammerer-Lercher, A;
Pulkki, K;
et al.
De Wolf, HA; Langlois, MR; Suvisaari, J; Aakre, KM; Baum, H; Collinson, P; Duff, CJ; Gruson, D; Hammerer-Lercher, A; Pulkki, K; Stankovic, S; Stavljenic-Rukavina, A; Laitinen, P; EFLM Task Group on Cardiac Markers
(2020)
How well do laboratories adhere to recommended guidelines for dyslipidaemia management in Europe? The CArdiac MARker Guideline Uptake in Europe (CAMARGUE) study.
Clin Chim Acta, 508.
pp. 267-272.
ISSN 1873-3492
https://doi.org/10.1016/j.cca.2020.05.038
SGUL Authors: Collinson, Paul
Abstract
BACKGROUND: The CArdiac MARker Guidelines Uptake in Europe Study (CAMARGUE) initiated by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) aims to survey the current use of evidence-based guidelines for dyslipidemia testing in Europe. METHODS: In 2019 a web-based questionnaire was distributed via EFLM National Societies to clinical laboratories in Europe. Questions covered pre-analytics, analytical methods, measurement units, flagging of decision thresholds, and use of decision-enhancing comments. RESULTS: Returns were obtained from 452 laboratories from 28 countries. Most laboratories always use nonfasting blood samples for lipid assays (66%). Lipid profiles are reported in mmol/L by 59% of the laboratories, mainly from 14 countries promoting the use of SI units. Important differences in flagging of decision thresholds were observed, with less than half of the laboratories applying the guideline-recommended LDL cholesterol threshold. Only 17% of the laboratories add an alert comment when familial hypercholesterolemia is suspected and 23% when risk of pancreatitis from hypertriglyceridemia is high. CONCLUSIONS: There are marked differences among laboratories in Europe in terms of pre-analytical, analytical, and post-analytical lipid management that could have an important clinical impact. This relates to different availability of assays or different laboratory practices on reporting and flagging of lipid profiles.
Item Type: |
Article
|
Additional Information: |
© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Keywords: |
Analytical, Guidelines, Lipids, Post-analytical, Pre-analytical, EFLM Task Group on Cardiac Markers, Guidelines, Lipids, Pre-analytical, Analytical, Post-analytical, Analytical, Guidelines, Lipids, Post-analytical, Pre-analytical, 1103 Clinical Sciences, General Clinical Medicine |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: |
Clin Chim Acta |
ISSN: |
1873-3492 |
Language: |
eng |
Dates: |
Date | Event |
---|
September 2020 | Published | 23 May 2020 | Published Online | 19 May 2020 | Accepted |
|
Publisher License: |
Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 |
PubMed ID: |
32454048 |
Web of Science ID: |
WOS:000549228300039 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/112030 |
Publisher's version: |
https://doi.org/10.1016/j.cca.2020.05.038 |
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