Barber, V; Calvert, A; Vandrevala, T; Star, C; Khalil, A; Griffiths, P; Heath, PT; Jones, CE
(2020)
Prevention of Acquisition of Cytomegalovirus Infection in Pregnancy Through Hygiene-based Behavioral Interventions: A Systematic Review and Gap Analysis.
Pediatr Infect Dis J, 39 (10).
pp. 949-954.
ISSN 1532-0987
https://doi.org/10.1097/INF.0000000000002763
SGUL Authors: Heath, Paul Trafford Jones, Christine Elizabeth Khalil, Asma Calvert, Anna Louise
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Abstract
BACKGROUND: Congenital cytomegalovirus infection is the most common nongenetic cause of sensorineural hearing loss in childhood and an important cause of neurodisability. There is no licensed cytomegalovirus (CMV) vaccine and no antenatal treatment for congenital CMV that is routinely recommended in clinical practice in the United Kingdom. OBJECTIVES: To review the published literature for studies that evaluated preventative hygiene-based interventions in pregnancy for their impact on knowledge about CMV prevention, the uptake of preventative behaviors or the acquisition of CMV in pregnancy. SEARCH STRATEGY: Searches were carried out in Medical Literature Analysis and Retrieval System Online and Cumulative Index of Nursing and Allied Health Literature databases. SELECTION CRITERIA: All human studies, limited to women of childbearing age were included. DATA COLLECTION AND ANALYSIS: Two reviewers independently assessed the quality of the methods and results of included articles. Extracted data were classified using Cochrane guidelines. MAIN RESULTS: Seven studies met the inclusion criteria. These show that preventative measures are acceptable to pregnant women, can impact their behavior and have the potential to reduce CMV in pregnancy. They are limited by several factors; sample size, nonrandomized trial design and interventions that are beyond routine clinical practice. CONCLUSIONS: An effective intervention that changes behavior in pregnancy and reduces the risk of CMV acquisition is needed as part of routine care. There is currently insufficient evidence about the form that this intervention should take. REGISTRATION: PROSPERO registration number: CRD42017069666.
Item Type: |
Article
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Additional Information: |
This is a non-final version of an article published in final form in Barber, V; Calvert, A; Vandrevala, T; Star, C; Khalil, A; Griffiths, P; Heath, PT; Jones, CE (2020) Prevention of Acquisition of Cytomegalovirus Infection in Pregnancy Through Hygiene-based Behavioral Interventions: A Systematic Review and Gap Analysis. Pediatr Infect Dis J, 39 (10). pp. 949-954. |
Keywords: |
congenital cytomegalovirus, pregnancy, hygiene intervention, behavioral change, 1114 Paediatrics and Reproductive Medicine, Pediatrics |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: |
Pediatr Infect Dis J |
ISSN: |
1532-0987 |
Language: |
eng |
Dates: |
Date | Event |
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October 2020 | Published | 3 June 2020 | Published Online | 29 April 2020 | Accepted |
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Publisher License: |
Publisher's own licence |
Projects: |
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PubMed ID: |
32502127 |
Web of Science ID: |
WOS:000573923900028 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/112015 |
Publisher's version: |
https://doi.org/10.1097/INF.0000000000002763 |
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