Carreras-Abad, C; Ramkhelawon, L; Heath, PT; Le Doare, K
(2020)
A Vaccine Against Group B Streptococcus: Recent Advances.
INFECTION AND DRUG RESISTANCE, 13.
pp. 1263-1272.
ISSN 1178-6973
https://doi.org/10.2147/IDR.S203454
SGUL Authors: Le Doare, Kirsty
Abstract
Group B streptococcus (GBS) causes a high burden of neonatal and infant disease globally. Implementing a vaccine for pregnant women is a promising strategy to prevent neonatal and infant GBS disease and has been identified as a priority by the World Health Organisation (WHO). GBS serotype-specific polysaccharide – protein conjugate vaccines are at advanced stages of development, but a large number of participants would be required to undertake Phase III clinical efficacy trials. Efforts are therefore currently focused on establishing serocorrelates of protection in natural immunity studies as an alternative pathway for licensure of a GBS vaccine, followed by Phase IV studies to evaluate safety and effectiveness. Protein vaccines are in earlier stages of development but are highly promising as they might confer protection irrespective of serotype. Further epidemiological, immunological and health economic studies are required to enable the vaccine to reach its target population as soon as possible.
Item Type: |
Article
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Additional Information: |
© 2020 Carreras-Abad et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution–Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
Keywords: |
Group B streptococcus, Streptococcus agalactiae, maternal vaccines, maternal immunisation, neonatal sepsis, infant sepsis, 1103 Clinical Sciences, 1115 Pharmacology and Pharmaceutical Sciences |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
INFECTION AND DRUG RESISTANCE |
ISSN: |
1178-6973 |
Dates: |
Date | Event |
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29 April 2020 | Published | 10 March 2020 | Accepted |
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Publisher License: |
Creative Commons: Attribution-Noncommercial 3.0 |
Web of Science ID: |
WOS:000529520300001 |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/111949 |
Publisher's version: |
https://doi.org/10.2147/IDR.S203454 |
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