D'Silva, A;
Captur, G;
Bhuva, AN;
Jones, S;
Bastiaenen, R;
Abdel-Gadir, A;
Gati, S;
van Zalen, J;
Willis, J;
Malhotra, A;
et al.
D'Silva, A; Captur, G; Bhuva, AN; Jones, S; Bastiaenen, R; Abdel-Gadir, A; Gati, S; van Zalen, J; Willis, J; Malhotra, A; Ster, IC; Manisty, C; Hughes, AD; Lloyd, G; Sharma, R; Moon, JC; Sharma, S
(2020)
Recreational marathon running does not cause exercise-induced left ventricular hypertrabeculation.
Int J Cardiol, 315.
pp. 67-71.
ISSN 1874-1754
https://doi.org/10.1016/j.ijcard.2020.04.081
SGUL Authors: Sharma, Sanjay Chis Ster, Delizia Irina
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Abstract
BACKGROUND: Marathon running in novices represents a natural experiment of short-term cardiovascular remodeling in response to running training. We examine whether this stimulus can produce exercise-induced left ventricular (LV) trabeculation. METHODS: Sixty-eight novice marathon runners aged 29.5 ± 3.2 years had indices of LV trabeculation measured by echocardiography and cardiac magnetic resonance imaging 6 months before and 2 weeks after the 2016 London Marathon race, in a prospective longitudinal study. RESULTS: After 17 weeks unsupervised marathon training, indices of LV trabeculation were essentially unchanged. Despite satisfactory inter-observer agreement in most methods of trabeculation measurement, criteria defining abnormally hypertrabeculated cases were discordant with each other. LV hypertrabeculation was a frequent finding in young, healthy individuals with no subject demonstrating clear evidence of a cardiomyopathy. CONCLUSION: Training for a first marathon does not induce LV trabeculation. It remains unclear whether prolonged, high-dose exercise can create de novo trabeculation or expose concealed trabeculation. Applying cut off values from published LV noncompaction cardiomyopathy criteria to young, healthy individuals risks over-diagnosis.
Item Type: | Article | ||||||
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Additional Information: | © 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | ||||||
Keywords: | 1102 Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology | ||||||
SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
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Journal or Publication Title: | Int J Cardiol | ||||||
ISSN: | 1874-1754 | ||||||
Language: | eng | ||||||
Dates: |
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Publisher License: | Creative Commons: Attribution 4.0 | ||||||
Projects: |
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PubMed ID: | 32360651 | ||||||
Go to PubMed abstract | |||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/111942 | ||||||
Publisher's version: | https://doi.org/10.1016/j.ijcard.2020.04.081 |
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