Kotronia, E; Wannamethee, SG; Papacosta, AO; Whincup, PH; Lennon, LT; Visser, M; Kapila, YL; Weyant, RJ; Ramsay, SE
(2021)
Poor oral health and inflammatory, haemostatic and cardiac biomarkers in older age: Results from two studies in the UK and USA.
J Gerontol A Biol Sci Med Sci, 76 (2).
pp. 346-351.
ISSN 1758-535X
https://doi.org/10.1093/gerona/glaa096
SGUL Authors: Whincup, Peter Hynes
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Abstract
BACKGROUND: We examined the association of objective and subjective oral health markers with inflammatory, haemostatic and cardiac biomarkers in older age. METHODS: Cross-sectional analyses were based on the British Regional Heart Study (BRHS) comprising British men aged 71-92 years (n=2147), and the Health, Aging and Body Composition (HABC) Study comprising American men and women aged 71-80 years (n=3075). Oral health markers included periodontal disease, tooth count, dry mouth. Inflammatory biomarkers included C-reactive protein (CRP), interleukin-6 (IL-6) in both studies, and tissue plasminogen activator (t-PA), von Willebrand Factor (vWF), fibrin D-dimer, high sensitivity Troponin T (hsTnT) and N-terminal pro-brain natriuretic peptide (NTproBNP) only in the BRHS. RESULTS: In both studies, tooth loss, was associated with the top tertile of CRP - odds ratios (95%CI) are 1.31 (1.02-1.68) in BRHS; and 1.40 (1.13-1.75) in the HABC Study, after adjusting for confounders. In the HABC Study, cumulative (≥3) oral health problems were associated with higher levels of CRP (OR (95%CI) =1.42 (1.01-1.99)). In the BRHS, complete and partial tooth loss were associated with haemostatic factors, in particular with the top tertile of fibrin D-dimer (OR (95%CI) = 1.64 (1.16-2.30) and 1.37 (1.05-1.77) respectively). Tooth loss and periodontal disease were associated with increased levels of hsTnT. CONCLUSIONS: Poor oral health in older age, particularly tooth loss, was consistently associated with some inflammatory, haemostatic and cardiac biomarkers. Prospective studies and intervention trials could help understand better if poor oral health is causally linked to inflammatory, haemostatic and cardiac biomarkers.
Item Type: |
Article
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Additional Information: |
This is a pre-copyedited, author-produced version of an article accepted for publication in Journals of Gerontology, Series A following peer review. The version of record Eftychia Kotronia, MSc, S Goya Wannamethee, PhD, A Olia Papacosta, MSc, Peter H Whincup, PhD, Lucy T Lennon, MSc, Marjolein Visser, PhD, Yvonne L Kapila, DDS, PhD, Robert J Weyant, DMD, DrPh, Sheena E Ramsay, PhD, Poor Oral Health and Inflammatory, Hemostatic, and Cardiac Biomarkers in Older Age: Results From Two Studies in the UK and USA, The Journals of Gerontology: Series A, Volume 76, Issue 2, February 2021, Pages 346–351 is available online at: https://doi.org/10.1093/gerona/glaa096 |
Keywords: |
C-reactive protein, Troponin T, cardiovascular disease, fibrin D-dimer, tooth loss, 1103 Clinical Sciences, Gerontology |
SGUL Research Institute / Research Centre: |
Academic Structure > Population Health Research Institute (INPH) |
Journal or Publication Title: |
J Gerontol A Biol Sci Med Sci |
ISSN: |
1758-535X |
Language: |
eng |
Dates: |
Date | Event |
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February 2021 | Published | 19 April 2020 | Published Online | 9 April 2020 | Accepted |
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Publisher License: |
Publisher's own licence |
Projects: |
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PubMed ID: |
32306041 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/111892 |
Publisher's version: |
https://doi.org/10.1093/gerona/glaa096 |
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