Tregoning, JS;
Weiner, J;
Cizmeci, D;
Hake, D;
Maertzdorf, J;
Kaufmann, SHE;
Leroux-Roels, G;
Maes, C;
Aerssens, A;
Calvert, A;
et al.
Tregoning, JS; Weiner, J; Cizmeci, D; Hake, D; Maertzdorf, J; Kaufmann, SHE; Leroux-Roels, G; Maes, C; Aerssens, A; Calvert, A; Jones, CE
(2020)
Pregnancy has a minimal impact on the acute transcriptional signature to vaccination.
NPJ Vaccines, 5.
p. 29.
ISSN 2059-0105
https://doi.org/10.1038/s41541-020-0177-6
SGUL Authors: Calvert, Anna Louise
Abstract
Vaccination in pregnancy is an effective tool to protect both the mother and infant; vaccines against influenza, pertussis and tetanus are currently recommended. A number of vaccines with a specific indication for use in pregnancy are in development, with the specific aim of providing passive humoral immunity to the newborn child against pathogens responsible for morbidity and mortality in young infants. However, the current understanding about the immune response to vaccination in pregnancy is incomplete. We analysed the effect of pregnancy on early transcriptional responses to vaccination. This type of systems vaccinology approach identifies genes and pathways that are altered in response to vaccination and can be used to understand both the acute inflammation in response to the vaccine and to predict immunogenicity. Pregnant women and mice were immunised with Boostrix-IPV, a multivalent vaccine, which contains three pertussis antigens. Blood was collected from women before and after vaccination and RNA extracted for analysis by microarray. While there were baseline differences between pregnant and non-pregnant women, vaccination induced characteristic patterns of gene expression, with upregulation in interferon response and innate immunity gene modules, independent of pregnancy. We saw similar patterns of responses in both women and mice, supporting the use of mice for preclinical screening of novel maternal vaccines. Using a systems vaccinology approach in pregnancy demonstrated that pregnancy does not affect the initial response to vaccination and that studies in non-pregnant women can provide information about vaccine immunogenicity and potentially safety.
Item Type: |
Article
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Additional Information: |
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
© The Author(s) 2020 |
Keywords: |
Immunology, Vaccines |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
NPJ Vaccines |
ISSN: |
2059-0105 |
Language: |
eng |
Dates: |
Date | Event |
---|
25 March 2020 | Published | 24 February 2020 | Accepted |
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Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
|
PubMed ID: |
32219001 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/111826 |
Publisher's version: |
https://doi.org/10.1038/s41541-020-0177-6 |
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