Drysdale, SB; Barr, RS; Rollier, CS; Green, CA; Pollard, AJ; Sande, CJ
(2020)
Priorities for developing respiratory syncytial virus vaccines in different target populations.
Sci Transl Med, 12 (535).
eaax2466.
ISSN 1946-6242
https://doi.org/10.1126/scitranslmed.aax2466
SGUL Authors: Drysdale, Simon Bruce
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Abstract
The development of an effective vaccine against respiratory syncytial virus (RSV) has been hampered by major difficulties that occurred in the 1960s when a formalin-inactivated vaccine led to increased severity of RSV disease after acquisition of the virus in the RSV season after vaccination. Recent renewed efforts to develop a vaccine have resulted in about 38 candidate vaccines and monoclonal antibodies now in clinical development. The target populations for effective vaccination are varied and include neonates, young children, pregnant women, and older adults. The reasons for susceptibility to infection in each of these groups may be different and, therefore, could require different vaccine types for induction of protective immune responses, adding a further challenge for vaccine development. Here, we review the current knowledge of RSV vaccine development for these target populations and propose a view and rationale for prioritizing RSV vaccine development.
Item Type: | Article | ||||||||||||
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Additional Information: | Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works | ||||||||||||
Keywords: | 11 Medical and Health Sciences, 06 Biological Sciences | ||||||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) | ||||||||||||
Journal or Publication Title: | Sci Transl Med | ||||||||||||
ISSN: | 1946-6242 | ||||||||||||
Language: | eng | ||||||||||||
Publisher License: | Publisher's own licence | ||||||||||||
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PubMed ID: | 32188721 | ||||||||||||
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URI: | https://openaccess.sgul.ac.uk/id/eprint/111805 | ||||||||||||
Publisher's version: | https://doi.org/10.1126/scitranslmed.aax2466 |
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