Dorrington, AM; Selinger, CP; Parkes, GC; Smith, M; Pollok, RC; Raine, T
(2020)
The historical role and contemporary use of corticosteroids in inflammatory bowel disease.
J Crohns Colitis, 14 (9).
pp. 1316-1329.
ISSN 1876-4479
https://doi.org/10.1093/ecco-jcc/jjaa053
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Abstract
The use of corticosteroids to treat patients with inflammatory bowel disease (IBD) has been the bedrock of IBD therapeutics since the pioneering work of Truelove and Witts in the UK in the 1950s and subsequent large cohort studies in the US and Europe. Nevertheless, whilst effective for induction of remission, these agents do not maintain remission and are associated with a long list of recognised side effects, including a risk of increased mortality. With the arrival of an increasing number of therapies for patients with IBD, the question arises as to whether we are using these agents appropriately in contemporary practice. This review discusses the historical background to steroid usage in IBD, and also provides a brief review of the literature on side effects of corticosteroid treatment as relevant to IBD patients. Data on licensed medications is presented with specific reference to the achievement of corticosteroid-free remission. We review available international data on the incidence of corticosteroid exposure and excess and discuss some of the observations we and others have made concerning healthcare and patient-level factors associated with the risk of corticosteroid exposure, including identification of 'at-risk' populations.
Item Type: |
Article
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Additional Information: |
This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Crohn's and Colitis following peer review. The version of record Alexander M Dorrington, Christian P Selinger, Gareth C Parkes, Melissa Smith, Richard C Pollok, Tim Raine, The Historical Role and Contemporary Use of Corticosteroids in Inflammatory Bowel Disease, Journal of Crohn's and Colitis, Volume 14, Issue 9, September 2020, Pages 1316–1329 is available online at: https://doi.org/10.1093/ecco-jcc/jjaa053 |
Keywords: |
Gastroenterology & Hepatology, 1103 Clinical Sciences |
Journal or Publication Title: |
J Crohns Colitis |
ISSN: |
1876-4479 |
Language: |
eng |
Dates: |
Date | Event |
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September 2020 | Published | 14 March 2020 | Published Online |
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Publisher License: |
Publisher's own licence |
PubMed ID: |
32170314 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/111801 |
Publisher's version: |
https://doi.org/10.1093/ecco-jcc/jjaa053 |
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