Frapwell, CJ; Skipp, PJ; Howlin, RP; Angus, EM; Hu, Y; Coates, ARM; Allan, RN; Webb, JS
(2020)
Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms.
Antimicrob Agents Chemother, 64 (5).
ISSN 1098-6596
https://doi.org/10.1128/AAC.02073-19
SGUL Authors: Coates, Anthony Robert Milnes Hu, Yanmin
Abstract
Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing Staphylococcus spp. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.
Item Type: |
Article
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Additional Information: |
Copyright © 2020 Frapwell et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/). |
Keywords: |
HT61, Staphylococcus aureus, antibiotics, biofilms, proteomics, HT61, Staphylococcus aureus, antibiotics, biofilms, proteomics, 0605 Microbiology, 1108 Medical Microbiology, 1115 Pharmacology and Pharmaceutical Sciences, Microbiology |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Antimicrob Agents Chemother |
ISSN: |
1098-6596 |
Language: |
eng |
Dates: |
Date | Event |
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May 2020 | Published | 21 April 2020 | Published Online | 25 February 2020 | Accepted |
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Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
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PubMed ID: |
32122902 |
Web of Science ID: |
WOS:000528256200033 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/111774 |
Publisher's version: |
https://doi.org/10.1128/AAC.02073-19 |
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