Cerasa, A; Fasano, A; Morgante, F; Koch, G; Quattrone, A
(2014)
Maladaptive plasticity in levodopa-induced dyskinesias and tardive dyskinesias: old and new insights on the effects of dopamine receptor pharmacology.
Front Neurol, 5.
p. 49.
ISSN 1664-2295
https://doi.org/10.3389/fneur.2014.00049
SGUL Authors: Morgante, Francesca
Abstract
Maladaptive plasticity can be defined as behavioral loss or even development of disease symptoms resulting from aberrant plasticity changes in the human brain. Hyperkinetic movement disorders, in the neurological or psychiatric realms, have been associated with maladaptive neural plasticity that can be expressed by functional changes such as an increase in transmitter release, receptor regulation, and synaptic plasticity or anatomical modifications such as axonal regeneration, sprouting, synaptogenesis, and neurogenesis. Recent evidence from human and animal models provided support to the hypothesis that these phenomena likely depend on altered dopamine turnover induced by long-term drug treatment. However, it is still unclear how and where these altered mechanisms of cortical plasticity may be localized. This study provides an up-to-date overview of these issues together with some reflections on future studies in the field, particularly focusing on two specific disorders (levodopa-induced dyskinesias in Parkinson's disease patients and tardive dyskinesias in schizophrenic patients) where the modern neuroimaging approaches have recently provided new fundamental insights.
Item Type: |
Article
|
Additional Information: |
Copyright: © 2014 Cerasa, Fasano, Morgante, Koch and Quattrone. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
Keywords: |
dopaminergic treatment, hyperkinetic movement disorders, inferior frontal cortex, levodopa-induced dyskinesias, tardive dyskinesias, levodopa-induced dyskinesias, tardive dyskinesias, hyperkinetic movement disorders, inferior frontal cortex, dopaminergic, 1109 Neurosciences, 1103 Clinical Sciences, 1701 Psychology |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: |
Front Neurol |
ISSN: |
1664-2295 |
Language: |
eng |
Dates: |
Date | Event |
---|
9 April 2014 | Published | 26 March 2014 | Accepted |
|
Publisher License: |
Creative Commons: Attribution 4.0 |
PubMed ID: |
24782822 |
Web of Science ID: |
WOS:000209629300049 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/111636 |
Publisher's version: |
https://doi.org/10.3389/fneur.2014.00049 |
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