Stylianou, E; Paul, MJ; Reljic, R; McShane, H
(2019)
Mucosal delivery of tuberculosis vaccines: a review of current approaches and challenges.
Expert Rev Vaccines, 18 (12).
pp. 1271-1284.
ISSN 1744-8395
https://doi.org/10.1080/14760584.2019.1692657
SGUL Authors: Paul, Mathew John
Abstract
Introduction: Tuberculosis (TB) remains a major health threat and it is now clear that the current vaccine, BCG, is unable to arrest the global TB epidemic. A new vaccine is needed to either replace or boost BCG so that a better level of protection could be achieved. The route of entry of Mycobacterium tuberculosis, the causative organism, is via inhalation making TB primarily a respiratory disease. There is therefore good reason to hypothesize that a mucosally delivered vaccine against TB could be more effective than one delivered via the systemic route.Areas covered: This review summarizes the progress that has been made in the area of TB mucosal vaccines in the last few years. It highlights some of the strengths and shortcomings of the published evidence and aims to discuss immunological and practical considerations in the development of mucosal vaccines.Expert opinion: There is a growing body of evidence that the mucosal approach to vaccination against TB is feasible and should be pursued. However, further key studies are necessary to both improve our understanding of the protective immune mechanisms operating in the mucosa and the technical aspects of aerosolized delivery, before such a vaccine could become a feasible, deployable strategy.
Item Type: |
Article
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Additional Information: |
© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: |
Tuberculosis, aerosol, challenges, delivery, mucosal, vaccination, Tuberculosis, vaccination, mucosal, aerosol, delivery, challenges, 1103 Clinical Sciences, Virology |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Expert Rev Vaccines |
ISSN: |
1744-8395 |
Language: |
eng |
Dates: |
Date | Event |
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December 2019 | Published | 26 December 2019 | Published Online | 11 November 2019 | Accepted |
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Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
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PubMed ID: |
31876199 |
Web of Science ID: |
WOS:000504386200001 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/111551 |
Publisher's version: |
https://doi.org/10.1080/14760584.2019.1692657 |
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