Perkin, MR;
Logan, K;
Bahnson, HT;
Marrs, T;
Radulovic, S;
Craven, J;
Flohr, C;
Mills, EN;
Versteeg, SA;
van Ree, R;
et al.
Perkin, MR; Logan, K; Bahnson, HT; Marrs, T; Radulovic, S; Craven, J; Flohr, C; Mills, EN; Versteeg, SA; van Ree, R; Lack, G; Enquiring About Tolerance (EAT) study team
(2019)
Efficacy of the Enquiring About Tolerance (EAT) study among infants at high risk of developing food allergy.
J Allergy Clin Immunol, 144 (6).
1606-1614.e2.
ISSN 1097-6825
https://doi.org/10.1016/j.jaci.2019.06.045
SGUL Authors: Perkin, Michael Richard
Abstract
BACKGROUND: The Enquiring About Tolerance (EAT) study was a randomized trial of the early introduction of allergenic solids into the infant diet from 3 months of age. The intervention effect did not reach statistical significance in the intention-to-treat analysis of the primary outcome. OBJECTIVE: We sought to determine whether infants at high risk of developing a food allergy benefited from early introduction. METHODS: A secondary intention-to-treat analysis was performed of 3 groups: nonwhite infants; infants with visible eczema at enrollment, with severity determined by SCORAD; and infants with enrollment food sensitization (specific IgE ≥0.1 kU/L). RESULTS: Among infants with sensitization to 1 or more foods at enrollment (≥0.1 kU/L), early introduction group (EIG) infants developed significantly less food allergy to 1 or more foods than standard introduction group (SIG) infants (SIG, 34.2%; EIG, 19.2%; P = .03), and among infants with sensitization to egg at enrollment, EIG infants developed less egg allergy (SIG, 48.6%; EIG, 20.0%; P = .01). Similarly, among infants with moderate SCORAD (15-<40) at enrollment, EIG infants developed significantly less food allergy to 1 or more foods (SIG, 46.7%; EIG, 22.6%; P = .048) and less egg allergy (SIG, 43.3%; EIG, 16.1%; P = .02). CONCLUSION: Early introduction was effective in preventing the development of food allergy in specific groups of infants at high risk of developing food allergy: those sensitized to egg or to any food at enrollment and those with eczema of increasing severity at enrollment. This efficacy occurred despite low adherence to the early introduction regimen. This has significant implications for the new national infant feeding recommendations that are emerging around the world.
Item Type: |
Article
|
Additional Information: |
© 2019 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: |
Food allergy, adherence, allergens, breastfeeding, diet, infancy, randomized controlled trial, Enquiring About Tolerance (EAT) study team, Allergy, 1107 Immunology |
SGUL Research Institute / Research Centre: |
Academic Structure > Population Health Research Institute (INPH) |
Journal or Publication Title: |
J Allergy Clin Immunol |
ISSN: |
1097-6825 |
Language: |
eng |
Dates: |
Date | Event |
---|
4 December 2019 | Published | 14 June 2019 | Accepted |
|
Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
|
PubMed ID: |
31812184 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/111474 |
Publisher's version: |
https://doi.org/10.1016/j.jaci.2019.06.045 |
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