Ding, Y; Wang, Y; Hsia, Y; Sharland, M; Heath, PT
(2019)
Systematic review of carbapenem-resistant Enterobacteriaceae causing neonatal sepsis in China.
Ann Clin Microbiol Antimicrob, 18 (1).
p. 36.
ISSN 1476-0711
https://doi.org/10.1186/s12941-019-0334-9
SGUL Authors: Heath, Paul Trafford Sharland, Michael Roy Hsia, Yingfen
Abstract
BACKGROUND: Carbapenems are β-lactam antibiotics which are used to treat severe infections caused by multidrug resistant Enterobacteriacea. The recent emergence and rapid spread of Enterobacteriaceae resistant to carbapenems is a global concern. We undertook a systematic review of the antibiotic susceptibility and genotypic characteristics of carbapenem-resistant Enterobacteriaceae in Chinese neonates. METHODS: Systematic literature reviews were conducted (PubMed/Medline, Embase, Wanfang medical online databases, China National Knowledge Infrastructure (CNKI) database) regarding sepsis caused by carbapenem-resistant Enterobacteriaceae in Chinese neonates aged 0-30 days. RESULTS: 17 studies were identified. Eleven patients in the six studies reported the source of infection. Ten patients (10/11, 90.9%) were hospital-acquired infections. Genotypic data were available for 21 isolates in 11 studies (20 K. pneumoniae, 1 E. coli). NDM-1 was the most frequently reported carbapenem-resistant genotype (81.0%, 17/21). Carbapenem-resistant Klebsiella pneumoniae and Escherichia coli were resistant to many antibiotic classes with the exception of colistin and fosfomycin. Sequence type 105 (ST105) was the most commonly reported K. pneumoniae ST type (30.8%; 4/13), which was from the same hospital in Western China. ST17 and ST20 were the second and third most common K. pneumoniae ST type, 23.1% (3/13) and 15.4% (2/13) respectively. The three strains of ST17 are all from the same hospital in central China. The two strains of ST20, although not from the same hospital, belong to the eastern part of China. CONCLUSIONS: Klebsiella pneumoniae with the NDM-1 genotype was the leading cause of neonatal carbapenem resistant sepsis in China. Hospital acquired infection is the main source of carbapenem resistant sepsis. There is currently no licenced antibiotic regimen available to treat such an infection in China. Improved surveillance, controlling nosocomial infection and the rational use of antibiotics are the key factors to prevent and reduce its spread.
Item Type: |
Article
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Additional Information: |
© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
Keywords: |
Carbapenem-resistant, Escherichia coli, Genotype, Klebsiella pneumoniae, Neonate, 1103 Clinical Sciences, Microbiology |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Ann Clin Microbiol Antimicrob |
ISSN: |
1476-0711 |
Language: |
eng |
Dates: |
Date | Event |
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14 November 2019 | Published | 29 October 2019 | Accepted |
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Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
Project ID | Funder | Funder ID |
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QML 20181207 | Beijing Hospitals Authority Youth Programme | UNSPECIFIED | 81872676 | National Natural Science Foundation of China | http://dx.doi.org/10.13039/501100001809 | 7192063 | Beijing Municipality Natural Science Foundation | UNSPECIFIED | XTYB201806 | Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Municipal Administration of Hospitals | UNSPECIFIED |
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PubMed ID: |
31727088 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/111327 |
Publisher's version: |
https://doi.org/10.1186/s12941-019-0334-9 |
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