Jansen, AC;
Belousova, E;
Benedik, MP;
Carter, T;
Cottin, V;
Curatolo, P;
D'Amato, L;
Beaure d'Augères, G;
de Vries, PJ;
Ferreira, JC;
et al.
Jansen, AC; Belousova, E; Benedik, MP; Carter, T; Cottin, V; Curatolo, P; D'Amato, L; Beaure d'Augères, G; de Vries, PJ; Ferreira, JC; Feucht, M; Fladrowski, C; Hertzberg, C; Jozwiak, S; Lawson, JA; Macaya, A; Marques, R; Nabbout, R; O'Callaghan, F; Qin, J; Sander, V; Sauter, M; Shah, S; Takahashi, Y; Touraine, R; Youroukos, S; Zonnenberg, B; Kingswood, JC
(2019)
Newly Diagnosed and Growing Subependymal Giant Cell Astrocytoma in Adults With Tuberous Sclerosis Complex: Results From the International TOSCA Study.
Front Neurol, 10.
p. 821.
ISSN 1664-2295
https://doi.org/10.3389/fneur.2019.00821
SGUL Authors: Kingswood, John Christopher
Abstract
The onset and growth of subependymal giant cell astrocytoma (SEGA) in tuberous sclerosis complex (TSC) typically occurs in childhood. There is minimal information on SEGA evolution in adults with TSC. Of 2,211 patients enrolled in TOSCA, 220 of the 803 adults (27.4%) ever had a SEGA. Of 186 patients with SEGA still ongoing in adulthood, 153 (82.3%) remained asymptomatic, and 33 (17.7%) were reported to ever have developed symptoms related to SEGA growth. SEGA growth since the previous scan was reported in 39 of the 186 adults (21%) with ongoing SEGA. All but one patient with growing SEGA had mutations in TSC2. Fourteen adults (2.4%) were newly diagnosed with SEGA during follow-up, and majority had mutations in TSC2. Our findings suggest that surveillance for new or growing SEGA is warranted also in adulthood, particularly in patients with mutations in TSC2.
| Item Type: |
Article
|
| Additional Information: |
Copyright © 2019 Jansen, Belousova, Benedik, Carter, Cottin, Curatolo, D'Amato, Beaure d'Augères, de Vries, Ferreira, Feucht, Fladrowski, Hertzberg, Jozwiak, Lawson, Macaya, Marques, Nabbout, O'Callaghan, Qin, Sander, Sauter, Shah, Takahashi, Touraine, Youroukos, Zonnenberg and Kingswood. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: |
SEGA, TOSCA, mTOR, registry, tuberous sclerosis complex, mTOR, registry, SEGA, TOSCA, tuberous sclerosis complex, 1109 Neurosciences, 1103 Clinical Sciences, 1701 Psychology |
| SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
| Journal or Publication Title: |
Front Neurol |
| ISSN: |
1664-2295 |
| Language: |
eng |
| Dates: |
| Date | Event |
|---|
| 2 August 2019 | Published | | 16 July 2019 | Accepted |
|
| Publisher License: |
Creative Commons: Attribution 4.0 |
| Projects: |
|
| PubMed ID: |
31428037 |
| Web of Science ID: |
WOS:000478639000001 |
 |
Go to PubMed abstract |
| URI: |
https://openaccess.sgul.ac.uk/id/eprint/111237 |
| Publisher's version: |
https://doi.org/10.3389/fneur.2019.00821 |
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