Sessa, M; Mascolo, A; Andersen, MP; Rosano, G; Rossi, F; Capuano, A; Torp-Pedersen, C
(2016)
Effect of Chronic Kidney Diseases on Mortality among Digoxin Users Treated for Non-Valvular Atrial Fibrillation: A Nationwide Register-Based Retrospective Cohort Study.
PLoS One, 11 (7).
e0160337.
ISSN 1932-6203
https://doi.org/10.1371/journal.pone.0160337
SGUL Authors: Rosano, Giuseppe Massimo Claudio
Abstract
PURPOSE: This study investigated the impact of chronic kidney disease on all-causes and cardiovascular mortality in patients with atrial fibrillation treated with digoxin. METHODS: All patients with non-valvular atrial fibrillation and/or atrial flutter as hospitalization diagnosis from January 1, 1997 to December 31, 2012 were identified in Danish nationwide administrative registries. Cox proportional hazard model was used to compare the adjusted risk of all-causes and cardiovascular mortality among patients with and without chronic kidney disease and among patients with different chronic kidney disease stages within 180 days and 2 years from the first digoxin prescription. RESULTS: We identified 37,981 patients receiving digoxin; 1884 patients had the diagnosis of chronic kidney disease. Cox regression analysis showed no statistically significant differences in all-causes (Hazard Ratio, HR 0.89; 95% confident interval, CI 0.78-1.03) and cardiovascular mortality (HR 0.88; 95%CI 0.74-1.05) among patients with and without chronic kidney disease within 180 days of follow-up period. No statistically significant differences was found using a 2 years follow-up period neither for all causes mortality (HR 0.90; 95%CI 0.79-1.03), nor for cardiovascular mortality (HR 0.87; 95%CI 0.74-1.02). No statistically significant differences was found comparing patients with and without estimated Glomerular Filtration Rate <30ml/min/1.73m2 and patients with different stages of chronic kidney disease, for all-causes and cardiovascular mortality within 180 days and 2 years from the first digoxin prescription. CONCLUSIONS: This study suggest no direct effect of chronic kidney disease and chronic kidney disease stages on all-causes and cardiovascular mortality within both 180 days and 2 years from the first digoxin prescription in patients treatment-naïve with digoxin for non-valvular atrial fibrillation.
Item Type: |
Article
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Additional Information: |
Copyright: © 2016 Sessa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
Keywords: |
Aged, Aged, 80 and over, Anti-Arrhythmia Agents, Atrial Fibrillation, Denmark, Digoxin, Female, Glomerular Filtration Rate, Humans, Kidney Failure, Chronic, Male, Proportional Hazards Models, Registries, Retrospective Studies, Survival Analysis, Humans, Kidney Failure, Chronic, Atrial Fibrillation, Digoxin, Anti-Arrhythmia Agents, Glomerular Filtration Rate, Registries, Proportional Hazards Models, Survival Analysis, Retrospective Studies, Aged, Aged, 80 and over, Denmark, Female, Male, MD Multidisciplinary, General Science & Technology |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: |
PLoS One |
ISSN: |
1932-6203 |
Language: |
eng |
Dates: |
Date | Event |
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28 July 2016 | Published | 18 July 2016 | Accepted |
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Publisher License: |
Creative Commons: Attribution 4.0 |
PubMed ID: |
27467520 |
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Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/111235 |
Publisher's version: |
https://doi.org/10.1371/journal.pone.0160337 |
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