Bratcher, HB;
Rodrigues, CMC;
Finn, A;
Wootton, M;
Cameron, JC;
Smith, A;
Heath, P;
Ladhani, S;
Snape, MD;
Pollard, AJ;
et al.
Bratcher, HB; Rodrigues, CMC; Finn, A; Wootton, M; Cameron, JC; Smith, A; Heath, P; Ladhani, S; Snape, MD; Pollard, AJ; Cunningham, R; Borrow, R; Trotter, C; Gray, SJ; Maiden, MCJ; MacLennan, JM
(2019)
UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence.
Wellcome Open Res, 4.
p. 118.
ISSN 2398-502X
https://doi.org/10.12688/wellcomeopenres.15362.2
SGUL Authors: Heath, Paul Trafford Ladhani, Shamez Nizarali
Abstract
Carriage of Neisseria meningitidis, the meningococcus, is a prerequisite for invasive meningococcal disease (IMD), a potentially devastating infection that disproportionately afflicts infants and children. Humans are the sole known reservoir for the meningococcus, and it is carried asymptomatically in the nasopharynx of ~10% of the population. Rates of carriage are dependent on age of the host and social and behavioural factors. In the UK, meningococcal carriage has been studied through large, multi-centre carriage surveys of adolescents in 1999, 2000, and 2001, demonstrating carriage can be affected by immunisation with the capsular group C meningococcal conjugate vaccine, inducing population immunity against carriage. Fifteen years after these surveys were carried out, invasive meningococcal disease incidence had declined from a peak in 1999. The UKMenCar4 study was conducted in 2014/15 to investigate rates of carriage amongst the adolescent population during a period of low disease incidence. The protocols and methodology used to perform UKMenCar4, a large carriage survey, are described here.
Item Type: |
Article
|
Additional Information: |
© 2019 Bratcher HB et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: |
Neisseria meningitidis, UKMenCar, adolescent, meningococcal carriage, population genomics, population immunity, Neisseria meningitidis, UKMenCar, adolescent, meningococcal carriage, population genomics, population immunity |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Wellcome Open Res |
ISSN: |
2398-502X |
Language: |
eng |
Dates: |
Date | Event |
---|
6 August 2019 | Published | 26 July 2019 | Accepted |
|
Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
|
PubMed ID: |
31544158 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/111228 |
Publisher's version: |
https://doi.org/10.12688/wellcomeopenres.15362.2 |
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