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Cryptococcal meningitis in apparently immunocompetent patients: association with idiopathic CD4+ lymphopenia.

Shribman, S; Noyce, A; Gnanapavan, S; Lambourne, J; Harrison, T; Schon, F (2018) Cryptococcal meningitis in apparently immunocompetent patients: association with idiopathic CD4+ lymphopenia. Pract Neurol, 18 (2). pp. 166-169. ISSN 1474-7766 https://doi.org/10.1136/practneurol-2017-001800
SGUL Authors: Harrison, Thomas Stephen

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Abstract

We present two cases of cryptococcal meningitis in people subsequently diagnosed with idiopathic CD4+ lymphopenia. Both presented with new onset headaches without sinister features and were sent home on multiple occasions from emergency departments. Cryptococcal meningitis in HIV-negative patients poses major diagnostic and management problems; the associated mortality is 9%-27%. We suggest performing blood and cerebrospinal fluid cryptococcal antigen tests in all people with lymphocytic meningitis.

Item Type: Article
Additional Information: This article has been accepted for publication in Practical Neurology, 2017 following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/practneurol-2017-001800. Copyright information: © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018.
Keywords: infectious diseases, lymphopaenia, meningitis, Adult, CD4-Positive T-Lymphocytes, Female, Humans, Lymphopenia, Male, Meningitis, Cryptococcal, Middle Aged, CD4-Positive T-Lymphocytes, Humans, Meningitis, Cryptococcal, Lymphopenia, Adult, Middle Aged, Female, Male, infectious diseases, lymphopaenia, meningitis, Neurology & Neurosurgery
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Pract Neurol
ISSN: 1474-7766
Language: eng
Dates:
DateEvent
27 March 2018Published
9 December 2017Published Online
7 November 2017Accepted
Publisher License: Publisher's own licence
PubMed ID: 29223998
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110957
Publisher's version: https://doi.org/10.1136/practneurol-2017-001800

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