Shribman, S; Noyce, A; Gnanapavan, S; Lambourne, J; Harrison, T; Schon, F
(2018)
Cryptococcal meningitis in apparently immunocompetent patients: association with idiopathic CD4+ lymphopenia.
Pract Neurol, 18 (2).
pp. 166-169.
ISSN 1474-7766
https://doi.org/10.1136/practneurol-2017-001800
SGUL Authors: Harrison, Thomas Stephen
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Abstract
We present two cases of cryptococcal meningitis in people subsequently diagnosed with idiopathic CD4+ lymphopenia. Both presented with new onset headaches without sinister features and were sent home on multiple occasions from emergency departments. Cryptococcal meningitis in HIV-negative patients poses major diagnostic and management problems; the associated mortality is 9%-27%. We suggest performing blood and cerebrospinal fluid cryptococcal antigen tests in all people with lymphocytic meningitis.
| Item Type: | Article |
|---|---|
| Additional Information: | This article has been accepted for publication in Practical Neurology, 2017 following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/practneurol-2017-001800. Copyright information: © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. |
| Keywords: | infectious diseases, lymphopaenia, meningitis, Adult, CD4-Positive T-Lymphocytes, Female, Humans, Lymphopenia, Male, Meningitis, Cryptococcal, Middle Aged, CD4-Positive T-Lymphocytes, Humans, Meningitis, Cryptococcal, Lymphopenia, Adult, Middle Aged, Female, Male, infectious diseases, lymphopaenia, meningitis, Neurology & Neurosurgery |
| SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) |
| Journal or Publication Title: | Pract Neurol |
| ISSN: | 1474-7766 |
| Language: | eng |
| Publisher License: | Publisher's own licence |
| PubMed ID: | 29223998 |
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Go to PubMed abstract |
| URI: | https://openaccess.sgul.ac.uk/id/eprint/110957 |
| Publisher's version: | https://doi.org/10.1136/practneurol-2017-001800 |
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