Dabhi, S; Duberly, K; Al-Nasir, J; Wijesiriwardana, N; Austen, BM
(2019)
Cyclisation of Cell Penetrating PDZ-Binding Peptides Directed to PSD95.
American Research Journal of Chemistry, 3 (1).
pp. 1-11.
ISSN 2577-5898
SGUL Authors: Austen, Brian Maxwell
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Abstract
Excitatory glutamatergic neurotransmission via N-methyl-D-aspartate receptor (NMDAR) is critical for synaptic plasticity and survival of neurons. Excessive NMDAR activity, however can cause excitotoxicity and promote cell death, underlying a potential mechanism of neurodegeneration occurring in Alzheimer’s disease (AD). The regulation of calcium levels at synapses is important for pre- and post-synaptic activation in the hippocampus, where glutamate is the primary neurotransmitter, acting via metabotropic and ionotropic receptors.
| Item Type: | Article | ||||||
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| Additional Information: | Copyright © 2019 Suraj Dabhi, Kate Duberly, Jamie Al-Nasir, Najith Wijesiriwardana, Brian Austen, This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | ||||||
| SGUL Research Institute / Research Centre: | Academic Structure > Institute of Medical & Biomedical Education (IMBE) Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE) |
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| Journal or Publication Title: | American Research Journal of Chemistry | ||||||
| ISSN: | 2577-5898 | ||||||
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| Publisher License: | Creative Commons: Attribution 4.0 | ||||||
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| URI: | https://openaccess.sgul.ac.uk/id/eprint/110837 |
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