Osborne, W; Chavda, A; Katritsis, G; Friedland, JS
(2019)
Lesson of the month 1: A rare adverse reaction between flucloxacillin and paracetamol.
Clin Med (Lond), 19 (2).
pp. 127-128.
ISSN 1473-4893
https://doi.org/10.7861/clinmedicine.19-2-127
SGUL Authors: Friedland, Jonathan Samuel
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Abstract
Flucloxacillin, a beta-lactam antibiotic, is a commonly prescribed antibiotic for the treatment of infections caused by staphylococci and streptococci, most notably Staphylococcus aureus Paracetamol is one of the most dispensed medications by NHS England and is used for the treatment of fever and pain.1 However most doctors are unaware that concurrent use of these drugs can cause a potentially fatal drug interaction due to pyroglutamic acidosis (PGA), also known as 5-oxoprolinaemia. PGA is a rare cause of raised anion gap metabolic acidosis due to disruption of the γ-glutamyl cycle. We report the case of a patient with multiple comorbidities who developed PGA due to coadministration of paracetamol and flucloxacillin.
| Item Type: | Article |
|---|---|
| Additional Information: | © Royal College of Physicians 2019. All rights reserved. |
| Keywords: | 5-oxoprolinaemia, Pyroglutamic acidosis, adverse drug reaction, flucloxacillin, metabolic acidosis, paracetamol, 1103 Clinical Sciences, General Clinical Medicine |
| Journal or Publication Title: | Clin Med (Lond) |
| ISSN: | 1473-4893 |
| Language: | eng |
| Publisher License: | Publisher's own licence |
| PubMed ID: | 30872293 |
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Go to PubMed abstract |
| URI: | https://openaccess.sgul.ac.uk/id/eprint/110763 |
| Publisher's version: | https://doi.org/10.7861/clinmedicine.19-2-127 |
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