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Synergistic activity of colistin with azidothymidine against colistin-resistant Klebsiella pneumoniae clinical isolates collected from inpatients in Greek hospitals.

Falagas, ME; Voulgaris, GL; Tryfinopoulou, K; Giakkoupi, P; Kyriakidou, M; Vatopoulos, A; Coates, A; Hu, Y; Colistin - Azidothymidine Hellenic Study Group (2019) Synergistic activity of colistin with azidothymidine against colistin-resistant Klebsiella pneumoniae clinical isolates collected from inpatients in Greek hospitals. Int J Antimicrob Agents, 53 (6). pp. 855-858. ISSN 1872-7913 https://doi.org/10.1016/j.ijantimicag.2019.02.021
SGUL Authors: Coates, Anthony Robert Milnes

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Abstract

BACKGROUND: New antibiotics are urgently needed for the treatment of multidrug resistant infections. However, the production of novel antibiotics is diminishing. The enhancement of activity of available antibiotics through synergistic combination drug therapy may help in the management of patients with resistant infections. METHODS: Colistin-resistant Klebsiella pneumoniae isolates were collected from inpatients in 10 Greek hospitals and used in the study of combination activity of colistin plus azidothymidine. The combination activity was evaluated with the sum of fractional inhibitory concentrations (ΣFIC), using the mini checkerboard broth microdilution method. RESULTS: 100 individual strains were tested. Synergistic activity was noted in 79% of the isolates (79/100) and additive activity in the rest 21% (21/100). ΣFIC50 and ΣFIC90 were 0.28 and 0.56, respectively. CONCLUSION: Colistin with azidothymidine exhibited promising synergistic activity against colistin-resistant carbapenem resistant Klebsiella pneumoniae isolates warranting further investigations of the combination.

Item Type: Article
Additional Information: © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Antiviral, Azidothymidine, Carbapenem, Colistin, Enterobacteriaceae, Gram-negative, Repurposing, Synergism, Colistin - Azidothymidine Hellenic Study Group, 1108 Medical Microbiology, 1115 Pharmacology And Pharmaceutical Sciences, Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Int J Antimicrob Agents
ISSN: 1872-7913
Language: eng
Dates:
DateEvent
June 2019Published
2 March 2019Published Online
26 February 2019Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
PubMed ID: 30836109
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110750
Publisher's version: https://doi.org/10.1016/j.ijantimicag.2019.02.021

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